| 银屑病样表现的移植物抗宿主病1例 |
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| 引用本文： | 黄锦萍,温炬,李婷,秦思,周玉婵,郑荣昌. 银屑病样表现的移植物抗宿主病1例[J]. 皮肤性病诊疗学杂志, 2022, 29(3): 253-256. DOI: 10.3969/j.issn.1674-8468.2022.03.012. |
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| 作者姓名： | 黄锦萍 温炬 李婷 秦思 周玉婵 郑荣昌 |
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| 作者单位： | 1. 广东省第二人民医院皮肤性病科，广东广州510317；2.广州市番禺区第二人民医院皮肤性病科，广东广州511470 |
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| 摘 要： | 报告1例罕见的银屑病样表现的移植物抗宿主病。患者女，35岁，头面部、四肢伸侧、躯干出现红色斑块，上覆银白色鳞屑。患者患急性B淋巴细胞白血病1年余，9个月前行异基因造血干细胞移植术。Auspitz’s阳性。组织病理同时具备银屑病样和界面皮炎样改变。免疫组化CD4+T细胞、CD8+T淋巴细胞浸润。诊断：银屑病样移植物抗宿主病。外用0.1%他克莫司软膏治疗1周后，皮损明显消退。
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| 关 键 词： | 造血干细胞移植 移植物抗宿主病 银屑病 白血病 |
A case of psoriasiform graft versus host disease |
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| HUANG Jinping,WEN Ju,LI Ting,QIN Si,ZHOU Yuchan,ZHENG Rongchang. A case of psoriasiform graft versus host disease[J]. Diagnosis and Therapy Journal of Dermato-Venereology, 2022, 29(3): 253-256. DOI: 10.3969/j.issn.1674-8468.2022.03.012. |
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| Authors: | HUANG Jinping WEN Ju LI Ting QIN Si ZHOU Yuchan ZHENG Rongchang |
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| Affiliation: | 1.Department of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou 510317, China； 2.Department of Dermatology, Guangzhou Panyu District Second People′s Hospital, Guangzhou 511470, China |
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| Abstract: | A rare case of psoriasiform graft-versus-host disease is reported. The patient suffered from acute B-cell leukemia for more than 1 year. Nine months after allogenic hematopoietic stem cell transplantation, the patient developed red papules and plaques, with Auspitz sign positive and silver-white scales on the head, face, limb and trunk. The histopathology showed both psoriatic and interfacial dermatitis. Immunohistochemical staining demonstrated infiltration of CD4+ and CD8+ T cells. Diagnosis was psoriasiform graft versus host disease. Lesions were improved by topical 0.1% tacrolimus ointment. |
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| Keywords: | hematopoietic stem cell transplantation graft versus host disease psoriasform,leukemia, |
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