浓缩生长因子在牙槽嵴保存和改善拔牙术后反应的临床效果Meta分析

 目的 系统评价浓缩生长因子(concentrated growth factor, CGF)在牙槽嵴保存和改善拔牙术后反应的临床效果。方法 通过Pubmed、Embase、Cochrane library、万方、维普、中国期刊全文、中国科技期刊和中国生物医学文献数据库等,检索所需文献。使用Cochrane手册对纳入研究的质量进行评估,采用Revman 5.4.1版软件进行Meta分析。结果 共纳入13个随机对照试验(randomized controlled trials, RCT),英文4篇,中文9篇。结果 可得:CGF可以减少拔牙后牙槽嵴高度的变化MD=-2.32(-3.83,-8.80), P<0.05]和宽度的变化MD=-1.67(-2.05,-1.29), P<0.05]。CGF可以降低拔牙后干槽症的发生率 OR=0.11 (0.03,0.38), P<0.05],但是CGF并不能改善下颌第三磨牙拔除术后张口受限情况MD=-0.27(-6.23,1.89)],通过定性分析得出CGF对改善下颌第三磨牙拔除后肿胀的效果不明确,但是可以缓解术后的疼痛。结论 CGF在牙槽嵴保存和改善拔牙术后反应等方面有着较好的临床效果。

Clinical effect of CGF in preservation of the alveolar ridge and amelioration of postoperative responses after tooth extraction:a Meta-analysis

Objective To assess the clinical effect of CGF in preservation of the alveolar ridge and amelioration of postoperative responses after tooth extraction.Methods Such electronic databases as Pubmed, Embase, Cochrane Library , Wanfang, CJFD, VIP, CQVIP and CBM were searched. The quality of the included studies was assessed using the Cochrane manual, and a meta-analysis was performed by using Revman 5.4.1.Results A total of 13 RCTs were included, 4 in English and 9 in Chinese. CGF could effectively reduce not only the height and width changes of the alveolar ridge after tooth extractionMD=-1.67(-2.05,-1.29), P<0.05], but also the incidence of dry sockets after tooth extractionOR=0.11 (0.03,0.38), P<0.05], but it could not effectively improve mouth opening after mandibular third molar extractionMD=-0.27(-6.23, 1.89), P>0.05]. Based on qualitative analysis, the effect of CGF on improving the swelling of mandibular third molar after extraction was not clear, but it could alleviate the postoperative pain.Conclusions CGF has a good clinical effect in preserving the alveolar ridge and ameliorating postoperative responses after tooth extraction.