| 复方麝香黄芪滴丸的体外及体内血清化学成分分析 |
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| 引用本文： | 李东红,胥芷灵,徐翠珊,王孟琰,张运克,贾永艳. 复方麝香黄芪滴丸的体外及体内血清化学成分分析[J]. 中国医院药学杂志, 2022, 42(6): 582-589. DOI: 10.13286/j.1001-5213.2022.06.02 |
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| 作者姓名： | 李东红 胥芷灵 徐翠珊 王孟琰 张运克 贾永艳 |
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| 作者单位： | 1. 河南中医药大学药学院, 河南 郑州 450046;2. 河南中医药大学康复医学院, 河南 郑州 450046;3. 河南省中药特色炮制技术工程研究中心, 河南 郑州 450046 |
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| 基金项目： | 国家自然科学基金项目（编号：81974564）；河南省高等学校重点科研项目（编号：20B360003）；河南中医药大学校级科研项目（编号：2019KYCX019） |
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| 摘 要： | 目的:应用超高效液相色谱-四级杆/静电场轨道阱高分辨质谱(UHPLC-Q-Orbitrap HRMS)对复方麝香黄芪滴丸的体外及体内血清化学成分进行快速分析鉴别.方法:采用Accucore C18(100 mm×2.1 mm,2.6 μm)色谱柱,以0.1％甲酸水溶液-甲醇梯度洗脱,流速0.2mL·min-1,进样量5...
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| 关 键 词： | 复方麝香黄芪滴丸 成分鉴定 超高效液相色谱-四级杆/静电场轨道阱高分辨质谱 血清 |
Analysis on the serum chemical components of compound Shexiang Huangqi dropping pills in vitro and in vivo |
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| LI Dong-hong,XU Zhi-ling,XU Cui-shan,WANG Meng-yan,ZHANG Yun-ke,JIA Yong-yan. Analysis on the serum chemical components of compound Shexiang Huangqi dropping pills in vitro and in vivo[J]. Chinese Journal of Hospital Pharmacy, 2022, 42(6): 582-589. DOI: 10.13286/j.1001-5213.2022.06.02 |
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| Authors: | LI Dong-hong XU Zhi-ling XU Cui-shan WANG Meng-yan ZHANG Yun-ke JIA Yong-yan |
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| Affiliation: | 1. Department of Pharmacy, Henan University of Chinese Medicine, Henan Zhengzhou 450046, China;2. School of Rehabilitation Medicine, Henan University of Chinese Medicine, Henan Zhengzhou 450046, China;3. Henan Research Center for Special Processing Technology of Chinese Medicine, Henan Zhengzhou 450046, China |
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| Abstract: | OBJECTIVE To quickly analyze and identify the serum chemical components of compound Shexiang Huangqi dropping pills in vitro and in vivo by ultra high performance liquid chromatography-four-stage bar/electrostatic field orbit well high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS).METHODS The test solution was separated on an Accucore C18 (100 mm×2.1 mm 2.6 μm) chromatographic column, and gradient elution was carried out with 0.1% formic acid solution-methanol as the mobile phase and the injection volume was 5 μL.RESULTS A total of 184 components with various types were identified with 26 common components in vitro and in vivo, including 42 flavonoids, 62 organic acids, 11 phthalides, 6 terpenes, 6 saponins, 4 coumarins, 2 alkaloids and 51 other compounds.CONCLUSION In the study, the prototype chemical constituents of compound Shexiang Huangqi dropping pills in vitro and in vivo were identified and analyzed successfully. |
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| Keywords: | compound Shexiang Huangqi dropping pills constituent identification UHPLC-Q-Orbitrap HRMS serum |
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