中晚期早产儿不良神经发育结局的研究进展

近年来,随着医疗水平的不断提高,早产儿存活率得以大幅提升,但由于胎龄不足,早产儿相比足月儿不良神经发育结局发生的风险比例增高,神经发育问题逐渐成为早产儿早期发展面临的突出问题。中晚期早产儿约占早产儿总人数的80％,但目前极早产和超早产与神经发育障碍相关性的研究较多,中晚期早产与神经发育障碍相关性的研究较少。本文对中晚期早产儿神经发育结局进行综述,为临床早期评估中晚期早产儿神经发育状态提供依据。通过胎盘-脑轴生物标志物预测中晚期早产儿神经发育结局,对开展早期干预具有重要意义。

Research progress in adverse neurodevelopmental outcomes of moderate or late preterm infants

In recent years, the survival rate of premature infants has greatly increased with the continuous improvement of medical level. However, due to insufficient gestational age, premature infants have a higher risk of adverse neurodevelopmental outcomes than full-term infants. And neurodevelopmental problems have gradually become a prominent problem faced by the early development of premature infants. Approximately 80% of the total number of preterm infants is moderate or late preterm infants. However, the correlation between extremely preterm birth and neurodevelopmental disorders is currently well studied, while there are few studies on the correlation between moderate or late preterm birth and neurodevelopmental disorders. In this paper, the neurodevelopmental outcomes of moderate or late preterm infants are reviewed in order to provide evidence for early clinical evaluation. It is of great significance for early intervention by predicting the neurodevelopmental outcome of moderate or late preterm infants by using placenta-brain axis biomarkers.