| 微针治疗皮肤感染的研究进展 |
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| 引用本文： | 王雪娇,赵锋,马银玲,连茹雨,曹德英.微针治疗皮肤感染的研究进展[J].中国医院药学杂志,2022,42(24):2698-2702. |
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| 作者姓名： | 王雪娇 赵锋 马银玲 连茹雨 曹德英 |
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| 作者单位： | 1. 河北医科大学药学院药剂学教研室, 河北 石家庄 050017;2. 河北省人民医院药学部, 河北 石家庄 050051 |
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| 基金项目： | 国家自然基金项目(编号:81773666);河北省自然科学基金项目(编号:H2021206275);河北省自然科学基金项目(编号:H2020307043);河北医科大学大学生创新性实验计划项目(编号:USIP2021019,USIP2021084) |
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| 摘 要： | 由真菌和细菌引起的皮肤感染很难通过传统外用的治疗药物达到完全消除,受皮肤角质层的存在或是感染生物膜的形成,药物在渗透到真皮组织时受到了极大的限制。微针因可无痛直接穿透表皮至真皮组织,提高药物的透皮率和治疗率,所以在治疗皮肤局部感染时更受关注,故本文总结了近年来微针在治疗真菌和细菌感染方面的研究,以期对皮肤局部抗菌治疗提供参考。
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| 关 键 词： | 微针 真菌 细菌 抗感染 皮肤感染 |
| 收稿时间： | 2022-04-29 |
Advances of microneedles in the treatment of skin infections |
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| WANG Xue-jiao,ZHAO Feng,MA Yin-ling,LIAN Ru-yu,CAO De-ying.Advances of microneedles in the treatment of skin infections[J].Chinese Journal of Hospital Pharmacy,2022,42(24):2698-2702. |
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| Authors: | WANG Xue-jiao ZHAO Feng MA Yin-ling LIAN Ru-yu CAO De-ying |
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| Institution: | 1. Department of Pharmaceutics School of Pharmacy, Hebei Medical University, Hebei Shijiazhuang 050017, China;2. Department of Pharmacy, Hebei General Hospital, Hebei Shijiazhuang 050051, China |
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| Abstract: | Skin infections caused by fungi and bacteria are difficult to be completely eliminated by traditional topical drugs.Due to the presence of cuticle or the formation of infected biofilms,the penetration of drugs into dermal tissue is extremely limited.Microneedles are more concerned in the treatment of local skin infections because they can directly penetrate epidermis to dermal tissue painlessly and improve the transdermal rate and treatment rate of drugs.Therefore,this paper summarizes the recent research of microneedles in the treatment of skin infections caused by fungal and bacterial,in order to provide reference for local antibacterial treatment of the skin. |
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| Keywords: | microneedles fungi bacteria anti-infection skin infection |
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