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| DNA甲基化在子宫内膜癌中的研究进展 | |
| 引用本文： | 阳丽君（综述）,黄瑾（审校）. DNA甲基化在子宫内膜癌中的研究进展[J]. 国外医学:妇产科学分册, 2009, 0(2): 117-122 |
| 作者姓名： | 阳丽君（综述） 黄瑾（审校） |
| 作者单位： | 中山大学附属中山医院妇产科; |
| 摘 要： | 子宫内膜癌是最常见的妇科恶性肿瘤之一，其发生是一个多步骤的过程，伴随着许多分子生物学的改变。越来越多的实验表明，在肿瘤的发生和发展中存在DNA甲基化水平和模式的混乱．包括基因组总体甲基化水平过低和某些基因启动子区域甲基化过高。DNA甲基化异常可通过影响染色质结构以及癌基因和抑癌基因表达而参与肿瘤的形成。现已在肿瘤的细胞周期调节基因、DNA错配修复基因、肿瘤抑制基因等多种基因中发现甲基化现象。了解目前对子宫内膜癌中DNA甲基化的研究进展有助于子宫内膜癌的早期发现和早期治疗。并改善预后。 |
| 关 键 词： | 子宫内膜癌 DNA甲基化 肿瘤抑制基因 DNA错配修复基因 p16 |
The Development of Study on DNA Methylation in Endometrial Carcinoma |
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| YANG Li-jun,HUANG Jin. The Development of Study on DNA Methylation in Endometrial Carcinoma[J]. Foreign Medical Sciences(Obstet Gynecol Fascicle), 2009, 0(2): 117-122 | |
| Authors: | YANG Li-jun HUANG Jin |
| Affiliation: | YANG Li-jun,HUANG Jin.Department of Obstetrics , Gynecology of the Zhongshan Hospital,Affiliated to Sun Yat-sen University,Zhongshan 528403,China |
| Abstract: | The endometrial carcinoma is a common malignant tumor of female reproductive tract, the carcinogenesis of which is a multi-step process, with many changes in molecular biology.More and more experiments have indicated that there is confusion in the level and pattern of DNA methylation during the carcinogenesis and development of tumor,which includes the low level of methylation in whole-genome and the high level of methylation in the promoter region .The DNA methylation may contribute to the genesis of tumor... |
| Keywords: | Endometrial carcinoma DNA methylation Tumor suppressor genes DNA Mismatch repair genes P16 |
| 本文献已被 CNKI 维普 等数据库收录！ | |