Resistance exercise relieves symptoms of vestibular migraine patients with MRI diagnosis: A randomized parallel-controlled single-blind clinical trial |
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| Affiliation: | 1. Department of MRI, Cangzhou Central Hospital, No. 16 Xinhua West Road, Yunhe District, 061001 Cangzhou, Hebei, China;2. Department of Neurology, Cangzhou Central Hospital, No. 16 Xinhua West Road, Yunhe District, 061001 Cangzhou, Hebei, China;3. Cheffe de service paramédical, ARAHM, 67000 Strasbourg, France;1. Neurology Department, Perpignan hospital, Perpignan, France;2. Regional health agency of Occitanie, Montpellier, France;3. Radiology Department, Perpignan hospital, Perpignan, France;4. Intensive care unit, Perpignan hospital, Perpignan, France;5. Neurology Department, University hospital of Montpellier, Montpellier, France;6. Neuroradiology Department, University hospital of Montpellier, Montpellier, France;1. Neurology department, Percy Military hospital, 92190 Clamart, France;2. Nuclear medicine department, Antoine-Béclère university Hospital, 92140 Clamart, France;3. Radiology department, Percy Military hospital, 92190 Clamart, France;4. Neurology department, neuro-oncology unit, Pitié-Salpêtrière university hospital, 75013 Paris, France;5. Centre Borelli, UMR 9010, université de Paris-Saclay, École normale supérieure Paris-Saclay, service de santé des armées, CNRS, université de Paris, INSERM, Paris, France;1. Department of Neurology, Hospital da Luz, Lisbon, Portugal;2. Headache Center, Hospital da Luz, Lisbon, Portugal;3. Department of Vascular Surgery, Centro Hospitalar Universitário de Lisboa Norte, Lisbon, Portugal;1. Ambulatory geriatric unit, Bretonneau hospital, Assistance publique–Hôpitaux de Paris, 23, rue Joseph-de-Maistre, 75018 Paris, France;2. Psychogeriatric unit, Bretonneau hospital, Assistance publique–Hôpitaux de Paris, 23, rue Joseph-de-Maistre, 75018 Paris, France;3. Inserm UMR-S 1144, université de Paris, Paris, France;1. U1172 – LilNCog – Lille Neuroscience & Cognition, university Lille, 59000 Lille, France;2. Department of neurology, CHU Lille, 59000 Lille, France;3. Department of neuroradiology, CHU Lille, 59000 Lille, France;4. CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 – UMS 2014 – PLBS, university Lille, 59000 Lille, France;1. Service de Neurologie et Pathologies du Mouvement, CHU Timone, APHM, Marseille, France;2. Centre D’Etudes et de Recherches sur les Services de Santé et Qualité, Faculté de Médecine, Aix-Marseille Université, Marseille, France;3. Service de Neurologie A, CHRU de Lille, Hôpital Roger Salengro, Marseille, France;4. Unité Neurologie cognitive, épilepsie, sommeil et mouvements anormaux, Département de Neurologie, CHU de Toulouse - Hôpital Purpan, Marseille, France;5. Service de Neurologie, CHU de Poitiers, Marseille, France;6. Unité Neurologie polyvalente, Département de neurologie, CHU de Rouen, Marseille, France;7. Service de Pathologie du mouvement–Neurologie, CHU de Strasbourg, Hôpital de Hautepierre, Marseille, France;8. Clinique neurologique, CHU de Nantes, Hôpital Nord Guillaume et René Laënnec, Marseille, France;9. Service de Neurologie, CHU de Montpellier, Marseille, France;10. Service de Neurologie, CHU Amiens-Picardie - Site Sud, Marseille, France;11. Département de Neurologie, Hôpital Universitaire de la Pitié-Salpêtrière, APHP, Marseille, France;12. Service de Neurologie, Hôpital Sainte Musse, Toulon, France;13. Service de neurologie, CHU de Clermont-Ferrand, Hôpital Gabriel Montpied, Marseille, France;14. Service de Neurologie, Hôpital Fondation Rothschild, Paris, France;15. Service de Neurologie, CHU de Nice, Marseille, France |
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| Abstract: | ![]()
To investigate the efficacy of resistance exercise on symptoms of vestibular migraine (VM) among migraine patients, a total of 385 VM patients were recruited, among whom 312 were eligible to participate in the current study. Patients were randomly allocated into either resistance exercise or relaxation control groups, and received respective interventions two times per week for 12 weeks. Patients were followed up at two and four months, respectively, to evaluate treatment effects. Primary outcomes included Dizziness Handicap Inventory (DHI), the number of vertiginous attacks in the previous week and Vertigo Severity Scale (VSS). Secondary endpoints included depression and anxiety symptoms, which were measured using the scores of the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory (BDI). Serum concentrations of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), were also assessed. Resistance exercise was slightly more pronounced in alleviating VM symptoms than relaxation control at two-month follow-up. While at four-month follow-up, the extents of the symptom attenuation were obviously better in the resistance exercise group than the relaxation control, in terms of VSS and DHI scores, as well as BDI and BAI scores. Serum levels of both TNF-α and IFN-γ were also significantly lower in patients in the resistance group than those in the relaxation control group. Our study favors an exercise-oriented treatment scheme in rehabilitating therapy for patients suffering from VM, and sheds light on the molecular mechanism potentially involving TNF-α and IFN-γ related inflammation pathways. |
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| Keywords: | Resistance exercise Vestibular migraine MRI Dizziness vertigo |
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