Analysis of Risk Factors for Delayed Graft Function After Kidney Transplantation |
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| Affiliation: | 1. Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea;2. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea;1. Department of Urology, Ankara City Hospital, Ankara, Turkey;2. Department of Radiology, Ankara City Hospital, Ankara, Turkey;3. Department of Urology, Bingol State Hospital, Bingol, Turkey;1. Renal Division, Department of Internal Medicine, Gospel Hospital, Kosin University College of Medicine, Busan, South Korea;2. Transplantation Research Institute, Kosin University College of Medicine, Busan, South Korea;3. Renal Pathology, Department of Pathology, Brigham & Women''s Hospital, Harvard Medical School, Boston, MA, USA;4. Transplantation Research Center, Renal Division, Brigham & Women''s Hospital, Harvard Medical School, Boston, Massachusetts, USA;1. Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;2. Excellence Center for Organ Transplantation, King Chulalongkorn Memorial Hospital, Bangkok, Thailand;3. Department of Surgery, BMA General Hospital, Bangkok, Thailand;1. Department of Blood Transfusion, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China;2. Department of Pathology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China;1. Xinqiao Hospital, Army Medical University (Third Military Medical University), No. 83 Xinqiao Street, Shapingba District, Chongqing, 400037, P.R. China;2. School of Nursing, Army Medical University (Third Military Medical University), No. 30 Gaotanyan Street, Shapingba District, Chongqing 400038, P.R. China |
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| Abstract: | BackgroundDelayed graft function (DGF) is a serious complication associated with worsening outcomes in kidney transplantation. To facilitate DGF risk reduction, this study aimed to identify the incidence and modifiable risk factors of this condition in kidney transplant patients.MethodsThis retrospective chart review included 220 patients who underwent kidney transplants between 2012 and 2021 at our kidney transplant center. Delayed graft function was defined as the requirement of hemodialysis within a week of transplantation. Clinical data from patients with DGF and those without this condition were compared to identify risk factors of DGF.ResultsOf 205 eligible patients, 20 (9.76%) developed DGF. In the univariate analysis, high hemoglobin level, deceased-donor type, and longer warm and cold ischemic times were significantly associated with DGF (P < .05). In the variable selection in logistic regression analysis, high hemoglobin level, with a cutoff value of 11.35 g/dL, and deceased-donor transplants were associated with higher DGF incidence (P < .05 for both factors).ConclusionsOur findings newly demonstrated that DGF occurred more frequently in patients with hemoglobin level >11.35 g/dL. As such, improvement in kidney transplantation outcomes could be achieved by reducing this modifiable risk factor. |
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