Arabic adaptation of the Edinburgh cognitive and behavioural Amyotrophic lateral sclerosis screen (ECAS-AR) |
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| Institution: | 1. Department of Neurology, LR18SP03, Razi University Hospital, 1 rue des Orangers, 2010 Tunis, Manouba, Tunisia;2. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia;3. Clinical Investigation Center (CIC) “Neurosciences and Mental Health”, Razi Universitary Hospital, 1 rue des orangers, Manouba, 2010 Tunis, Tunisia;1. Causal Dynamics, Plasticity and Rehabilitation Group, FRONTLAB team, office 3.028, Paris Brain Institute (Institut du Cerveau), CNRS UMR 7225, Inserm UMRS 1127 and Sorbonne Université, 47, boulevard de l’Hôpital, 75013 Paris, France;2. Laboratory of Functional Neurosciences (UR UPJV 4559), University Hospital of Amiens and University of Picardie Jules Verne, Amiens, France;3. Laboratory for Cerebral Dynamics Plasticity and Rehabilitation, Boston University School of Medicine, 700, Albany Street, Boston, MA W-702A, USA;4. Cognitive Neuroscience and Information Technology Research Program, Open University of Catalonia (UOC), Barcelona, Spain;1. Department of Physical Medicine and Rehabilitation, Mubarak Al-Kabeer Hospital, 43753 Jabriya, Kuwait;2. Department of Medicine, Faculty of Medicine, Kuwait University, 43753Jabriya, Kuwait;3. Division of Physical Medicine and Rehabilitation, Faculty of Medicine, University of British Columbia, V6T 1Z3 Vancouver, British Columbia, Canada;4. GF Strong Rehabilitation Centre, Vancouver, V5Z 2G9 British Columbia, Canada;1. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Neuroscience, Milano, Italy;2. Università degli studi di MIlano, Milano, Italy;3. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Department of Pediatric Rheumatology, Milano, Italy;1. Service de chirurgie du membre supérieur, pôle de chirurgie orthopédique et de traumatologie, hôpital Hautepierre 2, CHU Strasbourg, avenue Molière, 67000 Strasbourg, France;2. Pôle de santé publique, secteur méthodologie et biostatistiques, hôpitaux universitaires de Strasbourg, 1, place de l’Hôpital, 67000 Strasbourg, France;1. Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia;2. Neurology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia;1. Service de Neurologie, AP–HP, Hôpital Avicenne, Université Sorbonne Paris Nord, Bobigny, France;2. Consultation-Liaison Psychiatry and Psychiatric Emergency Department, Toulouse University Hospital, Toulouse, France;3. Pole de psychiatrie universitaire du grand Nancy, Centre Psychothérapeutique de Nancy, Laxou, France;4. Department of Neurology, Princess Alexandra Hospital, Brisbane, QLD, Australia;5. University of Queensland, Brisbane, QLD, Australia;6. ANAINF (Association Nationale des Assistants et Internes de Neurologie de France), France;7. Dynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, College de France, CNRS UMR7241/INSERM U1050, Université PSL, 75005 Paris, France;8. Institut du Cerveau et de la Moelle épinière - ICM, Inserm U1127, CNRS UMR 7225, Sorbonne Université, 75013 Paris, France |
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| Abstract: | Current screening batteries for assessing neuropsychological function are not specific for Amyotrophic Lateral Sclerosis (ALS) and are considered as limited tools due to the physical disabilities associated with ALS. The Edinburgh Cognitive and Behavioural ALS screen (ECAS) was developed to detect the specific cognitive and behavioral changes that may occur among ALS patients. This study presents the ECAS developed for Arabic-speaking ALS patients (ECAS-AR) for use by healthcare professionals. ECAS was translated and modified to refined variety of Arabic language. Eighty-five ALS patients were included. Normative data were collected from 200 healthy controls (among them 97 were matched). Subjects were administered the ECAS-AR and two conventional cognitive screening batteries, Frontal Assessment Battery (FAB) and Mini-Mental State Examination (MMSE). ECAS-AR discriminated well between healthy controls and ALS patients. Significant differences were noted in language, executive functions, memory, and visuospatial domains between the two groups. The most prevalent deficit occurred in language and executive functions in ALS-specific functions. Whereas memory was more readily impaired in the lower and middle education groups concerning ALS non-specific functions. Verbal fluency tended to be preserved. Positive correlations were found between ECAS-AR and the standard cognitive tests supporting its full validity. The ECAS-AR version proposed will provide rapid, efficient and sensitive tools for healthcare professional to determine the cognitive-behavioural profile in Arabic-speaking ALS patients. |
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| Keywords: | ECAS-AR Cognitive-behavioural profile screening Amyotrophic lateral sclerosis Arabic validation |
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