The Impact of Testosterone on the QT Interval: A Systematic Review |
| |
| Institution: | 1. Division of Cardiology, Kingston Health Science Center, Queen''s University, Kingston, Ontario, Canada;2. Division of Internal Medicine, Kingston Health Science Center, Queen''s University, Kingston, Ontario, Canada;3. Faculty of Health Sciences, School of Medicine, Queen''s University, Kingston, Ontario, Canada;1. Internal Medicine Department, Yerevan State Medical University after M. Heratsi, Yerevan, Republic of Armenia;2. Cardiology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Republic of Armenia;3. Internal Medicine Department, D. Halytsky Lviv National Medical University, Lviv, Ukraine;4. School of Medicine, Iran University of Medical Sciences, Teheran, Islamic Republic of Iran;5. Isfahan Cardiovascular-Research Center, Isfahan University of Medical Science, Isfahan, Islamic Republic of Iran;6. Clinical Pharmacology and Cardio-Oncology Department and Cardio-Oncology Center, M.D. Strazhesko Institute of Cardiology, Kiev, Ukraine;7. Sapienza University of Rome, Rome, Italy;8. School of Medicine, Insubria University Varese, Lombardy, Italy;9. Shupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine;10. Internal Disease Propedeutics Department, Yerevan State Medical University after M. Heratsi, Yerevan, Republic of Armenia;1. Federal State Budgetary Scientific Institution \"Russian Scientific Center of Surgery named B.V. Petrovsky\", Moscow, Russian Federation;2. City Alexandrovskaya Hospital, Saint Petersburg, Russian Federation;3. Federal State Budgetary Educational Institution of Higher Education, Military Medical Academy named after SM. Kirov, Saint Petersburg, Russian Federation;4. North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russian Federation;5. Research Institute Regional Clinical Hospital No. 1 named. prof. S.V. Ochapovsky , Krasnodar, Russian Federation;6. Department of Surgery No. 1 FPK and teaching staff of the Kuban State Medical University, Krasnodar, Russian Federation;7. Clinic of cardiac surgery of the Amur State Medical Academy of the Ministry of Health of Russia, Blagoveshchensk, Russian Federation;8. Clinic of high medical technologies named after N.I. Pirogov St. Petersburg State University, Saint Petersburg, Russian Federation;9. Kemerovo State Medical University of the Ministry of Health of the Russian Federation, Kemerovo, Russian Federation;10. Kemerovo Regional Clinical Hospital named after S.V. Belyaeva, Kemerovo, Russian Federation;1. Lehigh Valley Heart Institute, Lehigh Valley Health Network, Allentown, PA;2. Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY;3. Mira Loma High School, Sacramento, CA;4. Department of Internal Medicine, Carle Foundation Hospital, Urbana, IL;1. Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, Shenyang, People''s Republic of China;2. Department of Cardiology, The First Hospital of China Medical University, Shenyang, People''s Republic of China;3. Department of Ultrasound, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People''s Republic of China;1. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran;2. Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran;3. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran;1. Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX;2. Division of Cardiology, Baylor College of Medicine, Houston, TX;3. Division of Cardiology, University of Texas Medical Branch, Galveston, TX;4. Cardiovascular Institute, Baylor Scott & White - Temple, Temple, TX;5. Division of Pulmonary and Critical Care, University of Texas Medical Branch, Galveston, TX;6. Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX |
| |
| Abstract: | Humans and mammals have sex-specific differences in cardiac electrophysiology, linked to the action of sex hormones in the cardiac muscle. These hormones can upregulate or downregulate the expression of ionic channels modulating the cardiac cycle through genomic and non-genomic interactions. Systematic search in PubMed, Medline and EMBASE including keywords pertaining to testosterone and QT interval. Included experimental studies and observation studies and case reports presenting the results of testosterone administration, excess or deficiency in humans and animals. Testosterone has been shown to shorten the action potential duration, by enhancing the expression of K+ channels and downregulating ICaL increasing the repolarization reserve of the cardiac muscle. This effect has been observed in both genders and animals. Testosterone deficient states can promote arrhythmogenesis. The evidence in this paper may be used to guide clinical considerations, such as increased clinical surveillance of patients in testosterone deficient states using ECG. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
