Kidney Disease After Allogeneic Hematopoietic Stem Cell Transplantation Is Associated With Decreased Physical Function |
| |
| Affiliation: | 1. Rabindranath Tagore Hospital (Narayana Health Hospitals), Kolkata, India;2. Department of Nephrology and Transplantation, Rabindranath Tagore Hospital (Narayana Health Hospitals), Kolkata, India;1. General Surgery and Digestive System Department, Regional University Hospital of Málaga, Málaga, Spain;2. General Surgery and Digestive System Department, Clinic University Hospital of Málaga, Málaga, Spain;1. Department of Surgery, Ankara University School of Medicine, Ankara, Turkey;2. Department of Gastroenterology, Ankara Guven Hastanesi, Ankara, Turkey;3. Department of Gastroenterology, Hacettepe University School of Medicine, Ankara, Turkey;4. Department of Surgery, Ministry of Health Kecioren Training and Research Hospital, Ankara, Turkey;5. Department of Surgery, Ankara Guven Hastanesi, Ankara, Turkey;6. Department of Pediatric Surgery, Ankara University School of Medicine, Ankara, Turkey;1. Division of Nephrology, Department of Internal Medicine, Giresun University, Faculty of Medicine, Giresun, Turkey;2. Nephrology Clinic, Koc University Hospital, Istanbul, Turkey;3. Department of Biochemistry, Giresun University, Faculty of Medicine, Giresun, Turkey;4. and Division of Nephrology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey;1. Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Canada;2. Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Canada;1. Indiana University Division of Nephrology, Department of Medicine, Indianapolis, Indiana;2. Louisiana Organ Procurement Agency, New Orleans, Louisiana;3. Department of Surgery, University of Wisconsin, Madison, Wisconsin;4. Pediatric Critical Care, Akron Childrens’ Hospital, Akron, Ohio;5. Medical Director LifeCenter Northwest, Harborview Medical Center;6. Anesthesia and Pain Medicine; University of Washington, Seattle, Washington |
| |
| Abstract: | Objective/BackgroundAllogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved outcomes and prognosis, but it has many complications and is associated with impaired physical function. To solve this problem, it is necessary to further analyze the factors that cause the decline in physical function. In the present study, we hypothesized that kidney disease following allo-HSCT would be associated with impaired physical function, in addition to conventional factors, and tested this hypothesis retrospectively.MethodsThirty-one patients who underwent allo-HSCT at the Department of Hematology in our hospital from January 2016 to October 2021 were included in the analysis. Correlation analysis and stepwise multiple regression analysis with change in 30-second sit to stand test (Δ30-s STS) as the dependent variable were performed to identify predictors of physical function decline from pretransplant to discharge.ResultsThe mean age of participants was 43.9 years (SD = 11.8), the mean time from transplant to discharge was 103.1 days (SD = 35.0), and approximately 30% of patients had kidney disease following allo-HSCT. All patients were ambulatory and independent at discharge, but 30-s STS was significantly reduced (P < .001). Among various factors, age (β = ?0.464, P < .05), total corticosteroid dose (β = ?0.380, P < .05), and kidney disease after allo-HSCT (β = ?0.307, P < .05) were the independent predictors of Δ30-s STS (R2 = 0.592, adjusted R2 = 0.547, F = 13.072, P < .01).ConclusionKidney disease after allo-HSCT is one of the factors that may contribute to poor physical function, and patients who experience this condition may require additional follow-up to improve physical function. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
