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| HIV感染后CD8~+T细胞表面NK相关受体表达的变化 | |
| 引用本文： | 吴姗姗,姜拥军,张子宁,孙晓娟,刘静,丁海波,韩晓旭,楚振兴,尚红. HIV感染后CD8~+T细胞表面NK相关受体表达的变化[J]. 免疫学杂志, 2011, 0(10): 866-870,874 |
| 作者姓名： | 吴姗姗 姜拥军 张子宁 孙晓娟 刘静 丁海波 韩晓旭 楚振兴 尚红 |
| 作者单位： | 中国医科大学附属第一医院检验科卫生部艾滋病免疫学重点实验室;辽宁中医药大学附属医院临床检验中心; |
| 基金项目： | 国家科技重大专项课题资助项目(2008ZX10001-001,2008ZX10001-002); 国家重点基础研究发展计划(973计划)(2006CB504206); 辽宁省教育厅高等学校创新团队项目(辽教发[2008]117号2008T202) |
| 摘 要： | 目的深入了解人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染后CD8+T细胞表面NK相关受体表达的变化。方法选取25例未经高效抗逆转录病毒治疗的HIV感染者、11例AIDS患者、15例进行高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)者和13例HIV抗体阴性健康对照,用流式细胞仪检测研究对象外周血CD8+T细胞表面NKG2D、NKG2A和KIR3DL1的表达。结果 HIV感染后CD8+T细胞表面NKG2D表达的百分比显著低于健康对照,NKG2D+NKG2A-表达的百分比随疾病进展逐渐下降,且NKG2D+NKG2A-表达的百分比与CD4+T细胞的绝对数量呈正相关。AIDS患者CD8+T细胞表达NKG2A显著高于其它各组,随着疾病的进展CD8+T细胞表达NKG2A+NKG2D-百分比逐渐上升,AIDS患者显著高于其它各组,经抗逆转录病毒治疗后下降至健康对照的水平,且NKG2A+NKG2D-表达的百分比与CD4+T细胞的绝对数量呈负相关。HIV感染后CD8+T细胞KIR3DL1+表达的百分比较健康对照并无显著差异。结论 HIV感染机体后,CD8+T细胞NK相关受体表达变化与疾病进展相关,抗病毒治疗后可恢复其变化。 |
| 关 键 词： | CD8+T细胞 NKG2D NKG2A KIR3DL1 HIV |
Expressions of natural killer cell receptors on CD8~+ T cells of HIV-infected individuals |
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| WU Shanshan,JIANG Yongjun,ZHANG Zining,SUN Xiaojun,LIU Jing,DING Haibo,HAN Xiaoxu,CHU Zhenxing,SHANG Hong The Key Laboratory of AIDS Immunology of Ministry of Health. Expressions of natural killer cell receptors on CD8~+ T cells of HIV-infected individuals[J]. Immunological Journal, 2011, 0(10): 866-870,874 | |
| Authors: | WU Shanshan JIANG Yongjun ZHANG Zining SUN Xiaojun LIU Jing DING Haibo HAN Xiaoxu CHU Zhenxing SHANG Hong The Key Laboratory of AIDS Immunology of Ministry of Health |
| Affiliation: | WU Shanshan,JIANG Yongjun,ZHANG Zining,SUN Xiaojun,LIU Jing,DING Haibo,HAN Xiaoxu,CHU Zhenxing,SHANG Hong The Key Laboratory of AIDS Immunology of Ministry of Health,Department of Laboratory Medicine,First Hospital of China Medical University,Shenyang 110001,China |
| Abstract: | To better understand the alteration of natural killer cell associated receptors on CD8+ T cells of HIV infected individuals,peripheral blood was taken from 25 HIV infected individuals without treatment(HIV group),11 patients in AIDS stage(AIDS group),15 HIV infected patients with highly active antiretroviral therapy(HAART group) and 13 normal controls with negative HIV antibody(NC group).The expression of NKG2A,NKG2D and KIR3DL1 on CD8+ T cells surfaces was analyzed with flow cytometer.We found that the exp... |
| Keywords: | CD8 T cell NKG2D NKG2A KIR3DL1 HIV |
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