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| E-cadherin蛋白在乳腺导管癌中的表达及意义 | |
| 引用本文： | 赵卫,陈芙蓉,任宏政,王磊,樊琳蕊,陈奎生. E-cadherin蛋白在乳腺导管癌中的表达及意义[J]. 临床医学, 2012, 32(1): 28-30 |
| 作者姓名： | 赵卫 陈芙蓉 任宏政 王磊 樊琳蕊 陈奎生 |
| 作者单位： | 1. 河南省开封市第一人民医院病理科,开封,475000 2. 开封市第一人民医院肿瘤科,开封,475000 3. 郑州大学第一附属医院病理科 |
| 摘 要： | 目的 探讨E-cadherin蛋白在乳腺导管癌中的表达及意义.方法 采用免疫组化方法 检测E-cadherin蛋白在53例乳腺浸润性导管癌、25例导管内癌组织和13例乳腺囊性增生病组织中的表达.结果 E-cadherin蛋白在乳腺囊性增生组织、导管内癌及乳腺浸润性导癌中表达逐渐升高,差异有统计学意义.在浸润性导管癌中其表达与病理分级、脉管浸润和腋窝淋巴结转移显著相关.结论 E-cadherin与乳腺浸润性导管癌的发生、发展及淋巴结转移关系密切. |
| 关 键 词： | E-cadherin 乳腺癌 免疫组织化学 |
Clinical significance of E-cadherin expression in human breast invased ductal carcinoma |
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| ZHAO Wei,CHEN Fu-rong,REN Hong-zheng,WANG Lei,FAN Lin-rui,CHEN Kui-sheng. Clinical significance of E-cadherin expression in human breast invased ductal carcinoma[J]. Clinical Medicine, 2012, 32(1): 28-30 | |
| Authors: | ZHAO Wei CHEN Fu-rong REN Hong-zheng WANG Lei FAN Lin-rui CHEN Kui-sheng |
| Affiliation: | 1)Department of Pathology,the First People’s Hospital of Kaifeng,Kaifeng 475000,China;2)Department of Oncology,the First People’s Hospital of Kaifeng;3)Department of Pathology,the First Affiliated Hospital of Zhengzhou University |
| Abstract: | Objective To evaluate the expression level and clinical significance of E-cadherin in breast carcinoma.Methods The expression level of E-cadherin protein in 53 cases of invased breast ductal carcinoma,25 cases of breast intraductal carcinoma and 13 cases of cystic hyperplasia of breast were tested by the method of immunohistochemistry.Results The positive expression rate of E-cadherin in invased ductal breast carcinoma was lower than that of intraductal carcinoma and cystic hyperplasia of breast.The positive expression level of E-cadherin was descending with the upgrading of the breast invased ductal carcinoma pathological classification.Conclusion E-cadherin is closely associated with the carcinogenesis and development of breast ductal carcinoma. |
| Keywords: | E-cadherin Breast carcinoma Immunohistochemistry |
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