HER-2、HIF-1a、GLUT-1及VEGF表达在乳腺浸润性导管癌淋巴结转移中作用

目的 研究人表皮生长因子2(HER-2)与乏氧诱导因子1a(HIF-1a)、葡萄糖转运蛋白1(GLUT-1)、血管内皮生长因子(VEGF)在乳腺浸润性导管癌组织中的表达,探讨它们在乳腺浸润性导管癌淋巴结转移中的作用.方法 应用免疫组化SP法检测80例乳腺浸润性导管癌(腋淋巴结转移者36例、无腋淋巴结转移者44例)的HER-2、HIF-1a、GLUT-1及VEGF的表达情况,统计分析HER-2、HIF-1a、GLUT-1及VEGF与乳腺浸润性导管癌淋巴结转移的作用及其相关性.结果 HER-2、HIF-1a、GLUT-1及VEGF在乳腺浸润性导管癌腋淋巴结转移组比无腋淋巴结转移组明显高表达(P<0.05);HER-2与HIF-1a的表达呈正相关(r=0.411,P=0.000);HIF-1a与GLUT-1的表达呈正相关(r=0.389,P=0.000);HIF-1a与VEGF的表达呈正相关(r=0.425,P=0.000).结论 HER-2、HIF-1a、GLUT-1及VEGF在乳腺浸润性导管癌淋巴结转移中发挥重要作用,HER-2可能通过HIF-1a对GLUT-1、VEGF进行调控.

The role of HER-2,HIF-1a,GLUT-1 and VEGF in lymph node metastasis of breast invasive ductal carcinoma

Purpose To study the expression of HER-2,HIF-1a,GLUT-1 and VEGF in breast invasive ductal carcinoma and their role in lymph node metastasis.Methods Immunohistochemical staining was used to detect the expression of HER-2,HIF-1a,GLUT-1 and VEGF in 80 cases of breast invasive ductal carcinoma.Results The expressions of HER-2,HIF-1a,GLUT-1 and VEGF in carcinomas with lymph node metastasis were higher than those in carcinomas without lymph node metastasis(P<0.05).The positive expression rate of HER-2 had a positive correlation with those of HIF-1a(P=0.000,r=0.411).The positive expression rate of HIF-1a had a positive correlation with those of GLUT-1(P=0.000,r=0.389).The positive expression rate of HIF-1a had a positive correlation with those of VEGF(P=0.000,r=0.425).Conclusion HER-2,GLUT-1,VEGF and HIF-1a may be important role in the lymph node metastasis of breast invasive ductual carcinoma,and HER-2 may be regulated by GLUT-1 and VEGF in breast carcinoma.