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| DEC-205对病毒抗原的提呈机制及其作为分子内佐剂的研究进展 | |
| 引用本文： | 潘玉竹,罗小莉,孔祥军,吕凤林. DEC-205对病毒抗原的提呈机制及其作为分子内佐剂的研究进展[J]. 免疫学杂志, 2011, 0(11): 996-1000 |
| 作者姓名： | 潘玉竹 罗小莉 孔祥军 吕凤林 |
| 作者单位： | 重庆大学生物工程学院; |
| 基金项目： | 重庆市自然科学基金(CSTC2009BA5068) |
| 摘 要： | DEC-205是一种表达于大多数APC细胞的I型跨膜蛋白,属于甘露糖受体家族。DEC-205在抗原的内化、处理及呈递中扮演重要角色。但DEC-205介导抗原内化、提呈的机制并未被探明,尤其是其在介导抗原交叉提呈机制以及作为疫苗分子内佐剂等方面。本文通过对DEC-205的结构的认识,详细分析了国内外关于抗原提呈机制和DEC-205的研究进展,总结了DEC-205作为分子内佐剂角色的研究现状。 |
| 关 键 词： | DEC-205 APC细胞 抗原提呈 交叉提呈 |
Mechanism of DEC-205 presenting viral antigen and its prospect as a built-in adjuvant |
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| PAN Yuzhu,LUO Xiaoli,KONG Xiangjun,L FenglinCollege of Bioengineering,Chongqing University,Chongqing ,China. Mechanism of DEC-205 presenting viral antigen and its prospect as a built-in adjuvant[J]. Immunological Journal, 2011, 0(11): 996-1000 | |
| Authors: | PAN Yuzhu LUO Xiaoli KONG Xiangjun L FenglinCollege of Bioengineering Chongqing University Chongqing China |
| Affiliation: | PAN Yuzhu,LUO Xiaoli,KONG Xiangjun,L FenglinCollege of Bioengineering,Chongqing University,Chongqing 400044,China |
| Abstract: | DEC-205,belonging to mannose receptor family,is one of the transmembrane proteins I which express in most of APCs which.DEC-205 plays a critical role in antigen internalization,process and presentation.However,its intracellular mechanism involved in these process are not defined,especially the cross-presentation.This paper will introduce the construction and function of DEC-205,analyze the development of research on DEC-205 mediate antigen presentation,and summarize the study of DEC-205 as built-in adjuvant... |
| Keywords: | DEC-205 APCs Antigen presentation Cross-presentation |
| 本文献已被 CNKI 等数据库收录！ | |