鼻咽癌放射治疗后原发肿瘤体积变化的分析

目的观察鼻咽癌放疗后原发肿瘤体积的变化并分析其相关因素。方法回顾性分析46例接受放射治疗的鼻咽癌患者的临床资料，主要包括患者的年龄、性别、病理类型和生长类型、原发肿瘤体积（VO）以及放射治疗结束时残留肿瘤体积（V70）、原发肿瘤最大截面积、T分期和N分期、照射剂量等因素。采用二项分类Logistic回归分析法分析这些因素和放疗50Gy时肿瘤退缩率的关系。结果分析结果显示，肿瘤病理类型和生长类型、T分期、N分期、照射剂量与肿瘤消退有密切关系（P〈0．05）。结论肿瘤体积的变化可较好的反映放疗的效果，明确肿瘤消退的相关因素，可以指导临床治疗，预后判断，提高患者生存率。

The analysis of primary tumor volume change of nasopharyngeal carcinoma patients treated with radiotherapy

Objective To analyze influential factors of primary tumor volume change of nasopharyngeal carcinoma(NPC) patients treated with radiotherapy.Methods The information of 46 NPC patients proved by pathology who received radiotherapy were analyzed retrospectively and the relationship between the regression rate of tumor delivered 50 Gy and age,sex,histological type and growth type,primary tumor volume,remain tumor volume of radiation treatment,cross section,T stage and N stage,radiation dose were analyzed.Results histological type and growth type,T stage and N stage,radiation dose were significantly associated with the regression rate of tumor delivered 50Gy(V50/V0).Conclusions The regression rate of tumor is a good index in primary efficacy evaluation and can partly reflect effect of radiotherapy.Explication the the related factors of the regression rate of tumor,can guide clinical treatment and prognosis judgment and improve patient survival rate.