| 骨髓间充质干细胞与糖尿病及其并发症的治疗 |
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| 引用本文： | 李佳萦,冯烈. 骨髓间充质干细胞与糖尿病及其并发症的治疗[J]. 国际内分泌代谢杂志, 2009, 29(6). DOI: 10.3760/cma.j.issn.1673-4157.2009.06.009 |
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| 作者姓名： | 李佳萦 冯烈 |
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| 作者单位： | 暨南大学附属第一医院内分泌科,广州,510630;暨南大学附属第一医院内分泌科,广州,510630 |
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| 摘 要： | 传统的药物治疗不能阻止糖尿病患者胰岛β细胞的进行性衰竭.骨髓间充质干细胞是一个缺乏造血干细胞的细胞群,具有自我更新能力以及多向分化潜能,可定向诱导分化为胰岛素分泌细胞,分泌胰岛素,从而可能用于糖尿病及其并发症的治疗.胰-十二指肠同源盒因子-1可提高其分化效率.本文主要对骨髓间充质干细胞治疗糖尿病及其并发症作一综述.
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| 关 键 词： | 骨髓间充质干细胞 糖尿病 胰岛素分泌细胞 胰-十二指肠同源盒因子-1 |
Bone marrow-derived mesenchymal stem cells in therapy of diabetes and its complications |
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| LI Jia-ying,FENG Lie. Bone marrow-derived mesenchymal stem cells in therapy of diabetes and its complications[J]. International JOurnal of Endocrinology and Metabolism, 2009, 29(6). DOI: 10.3760/cma.j.issn.1673-4157.2009.06.009 |
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| Authors: | LI Jia-ying FENG Lie |
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| Abstract: | Traditional medication of diabetes can not hold back the progressive failure of pancreatic β-cells.Bone marrow mesenchymal stem cells (BMSCs) are cell populations lack of hematopoietic stem cell,which have the ability of self-renewal and multi-directional differentiation potentiality.Recent reports showed that BMSCs could differentiate into endocrine cells of pancreas and secret insulin.This may provide a source of cell-based therapy for patients with diabetes mellitus.In addition,recent reports also showed that pancreatic duodenal homeobox-1(PDX-1)may be useful in enhancing insulin secretion.This paper introduces research progress of bone marrow-derived mesenchynml stem cells in therapy of diabetes and its complications. |
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| Keywords: | Bone marrow mesenchymal stem cells Diabetes mellitus Insulin-secreting cells Pancreatic duodenal homeobox-1 |
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