|
|||||
|
|
| 增殖细胞核抗原与胃癌淋巴结转移的关系 | |
| 引用本文： | 戴林 张学庸. 增殖细胞核抗原与胃癌淋巴结转移的关系[J]. 医学争鸣, 1996, 17(3): 169-171 |
| 作者姓名： | 戴林 张学庸 |
| 作者单位： | 第四军医大学西京医院消化内科，第四军医大学病理学教研室 |
| 摘 要： | 研究增殖细胞核抗原与胃癌淋巴结转移的关系和意义。采用ＡＢＣ免疫组织化学染色法对４４例经福尔马林固定，石蜡包埋的胃癌手术标本进行半定量检测，观察ＰＣＮＡ与淋巴结转移和胃癌组织学类型的关系。伴淋巴结转移组ＰＣＮＡ高表达者占７６．２％。显著高于无转移组１３％，两者呈显著相关联。 |
| 关 键 词： | 增殖细胞核 抗原 胃肿瘤 淋巴结转移瘤 |
Relation between proliferating cell nuclear antigen in gastric carcinoma and its lymph node metastasis |
|
| Dai Lin ,Zhang Xueyong ,Chen Baojun ,Wang Jianbo ,Zhang Huizhong ,Fan Daiming. Relation between proliferating cell nuclear antigen in gastric carcinoma and its lymph node metastasis[J]. Negative, 1996, 17(3): 169-171 | |
| Authors: | Dai Lin Zhang Xueyong Chen Baojun Wang Jianbo Zhang Huizhong Fan Daiming |
| Affiliation: | Dai Lin 1,Zhang Xueyong 1,Chen Baojun 1,Wang Jianbo 2,Zhang Huizhong 2,Fan Daiming 1 1Department of Gastroenterology,Xijing Hospital,Fourth Military Medical University,Xi'an 710033 2Department of Pathology,Fourth Military Medical Un |
| Abstract: | Objective: To study the correlation between proliferating cell nuclear antigen (PCNA) and lymph node metastasis of gastric carcinoma. Methods: Formalin fixed, paraffin embedded, surgically resected tissue specimens of 44 gastric carcinoma were investigated by ABC immunohistochemical staining. Lymph node metastasis and histological grade were examined. Results: The PCNA expression in both cases of lymph node metastasis (76%, 16/21) and poorly differentiated gastric carcinoma (68.4%, 13/19) were significantly higher than in those without metastasis (13%, 3/23) ( P <0.05), and in well/moderately differentiated type (24%, 6/25) ( P <0.01). Conclusion: The presence of PCNA in patients with lymph node metastasis were significantly higher than those without lymph node metastasis. These data suggest that PCNA is a fairly good index to indicate lymph node metastasis of gastric carcinoma. |
| Keywords: | proliferating cell nuclear antigen stomach neoplasms lymph node metastasis |
| 本文献已被 CNKI 维普 等数据库收录！ | |