计算法测定肾小球滤过率的临床应用价值

目的 :探讨采用 WCP公式计算方法测定肾小球滤过率 (GFR)的临床应用价值。方法 :采用 99m Tc DTPA清除率测定 6 6例不同疾病住院患者 GFR(Tc GFR) ,并测血清肌酐 (SCr)及尿素氮 (BU N) ,同时以 WCP公式、Robert公式计算 GFR(WCP GFR,Robert GFR) ,以 Cockcroft/ Gault公式计算内生肌酐清除率 (CG CCr) ,所得数据进行对比研究及相关性分析。结果 :除肾功能正常者 CG CCr与 BU N无显著相关外 ,肾功能不全及肾功能正常者的 WCP GFR、Robert GFR、CG CCr均分别与 Tc GFR呈显著正相关(P均 <0 .0 1) ,与 BU N、SCr呈显著负相关 (P<0 .0 1或 P<0 .0 5 ) ;与 Robert GFR、CG CCr比较 ,WCPGFR始终与 Tc GFR最接近 (P均 >0 .0 5 ) ;WCP GFR、Robert GFR、CG CCr与 Tc GFR的平均差绝对值逐渐增大 ,三者间差异显著 (P均 <0 .0 5 )。结论 :WCP GFR、Robert GFR、CG CCr均能在一定程度上准确反映 GFR,而以 WCP GFR更准确 ,且简便、快速、安全而廉价 ,可代替 Tc GFR应用于临床

Value of clinical application of determining glomerular filtration rate by the calculation method

Objective:To assess the value of clinical application of determining glomerular filtration rate(GFR) by the calculation method.Methods:GFRs from 66 patients in hospital suffering from various diseases were accurately determined using clearance rate of 99m TcDTPA(TcGFR).Serum creatinine(Cr) and blood urea nitrogen(BUN) contents were measured,and simultaneously GFRs were calculated by WCP formula and Robert formula(WCPGFR and RobertGFR).Creatinine clearance rate was calculated by Cockcroft/Gault formula(CGCCr).The contrast study and correlation analysis were done for the data.Results:In patients with or without renal insufficiency,WCPGFR,RobertGFR,and CGCCr were positively correlated with TcGFR (all P <0 01) but negatively with BUN and serum Cr( P <0 05 or 0 01),respectively,with an exception between CGCCr and BUN in those without renal dysfunction.WCPGFR was more accurate than the others and could take the place of TcGFR clinically.Conclusions:WCPGFR,RobertGFR,and CGCCr might be helpful to reflect GFR to certain extent.Of them,WCPGFR was an accurate,simple,safe,and cheap method for determining GFR and it should be used and popularized clinically.