高血压病合并心律失常患者脂联素与脑钠肽相关

目的:探讨高血压病及高血压合并心律失常患者血清脂联素水平,及其与脑钠肽(BNP)、C-反应蛋白(CRP)的相关性.方法:选取原发性高血压病患者71例,分为单纯高血压组(36例)及合并心律失常组(35例).测定血清脂联素、BNP、CRP水平,并进行相关性分析.结果:合并心律失常组(0.977±0.340)mg/L]及单纯高血压病组(1.977±0.990)mg/L]脂联素浓度显著低于正常对照组(6.451±1.972)mg/L](P<0.01),合并心律失常组脂联素浓度显著低于单纯高血压组(P<0.01).合并心律失常组及单纯高血压组BNP、CRP浓度高于正常对照组,合并心律失常组BNP、CRP浓度显著高于单纯高血压组(P<0.01).单纯高血压组及合并心律失常组血清脂联素与BNP、CRP均呈负相关.结论:高血压病患者,血清脂联素降低、CRP及BNP水平升高,合并心律失常的高血压患者上述指标改变更为显著.血清脂联素与血清BNP、CRP呈负相关.脂联素可能与高血压病发生、发展有关.

Circulating adiponectin in relation to brain natriuretic peptide in hypertensive subjects with arrhythmia subjects

Objective:To study the significance of variance in plasma adiponectin(APN) in hypertensive patients with arrhythmia, and the relationship between plasma APN and brain natriuretic peptide(BNP), c-reactive protein(CRP). Methods:The study comprised 71 hypertensive subjects who were divided into 2 groups, 35 of whom were hypertension with arrhythmia, the other were simplex hypertensive subjects. The plasma APN, BNP and CRP were determined. The relationship between them were tested. Results: Plasma APN levels si...