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| 鲑鱼降钙素对小鼠腹腔巨噬细胞释放一氧化氮的影响 | |
| 引用本文： | 嵇扬 陆红 吴敏. 鲑鱼降钙素对小鼠腹腔巨噬细胞释放一氧化氮的影响[J]. 中国骨质疏松杂志, 2002, 8(4): 352-354 |
| 作者姓名： | 嵇扬 陆红 吴敏 |
| 作者单位： | 1. 100071,北京,解放军总后勤部卫生部药品仪器检验所 2. 空军四六三医院 |
| 摘 要： | 目的：研究鲑鱼降钙素对小鼠腹腔巨噬细胞释放一氧化氮的影响。方法：NO以Griess试剂测定。结果：效价为1－8U/ml的鲑鱼降钙素能显抑制小鼠腹腔巨噬细胞一氧化氮释放，呈现剂量依赖性，抑制率为7．75％－71．44％，结论：鲑鱼降钙素对小鼠腹腔巨噬细胞释放一氧化氮的抑制作用可能是其骨质疏松治疗作用的机理之一。 |
| 关 键 词： | 鲑鱼降钙素 一氧化氮 巨噬细胞 肽类血钙调节激素 骨质疏松 |
| 修稿时间： | 2001-11-19 |
Effect of Salcatonin on lipopolysaccharide-induced release of nitric oxide from mouse peritoneal microphase in vitro |
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| JI Yang,LU Hong,WU Min.Institute for Drug and Instrument Control General Rear service. Effect of Salcatonin on lipopolysaccharide-induced release of nitric oxide from mouse peritoneal microphase in vitro[J]. Chinese Journal of Osteoporosis, 2002, 8(4): 352-354 | |
| Authors: | JI Yang LU Hong WU Min.Institute for Drug Instrument Control General Rear service |
| Affiliation: | JI Yang,LU Hong,WU Min.Institute for Drug and Instrument Control General Rear service Department of PLA,Beijing 100071,China |
| Abstract: | Objective To investigate the effects of Salcatonin on LPS induced release of NO from mouse peritoneal microphase in vitro . Methods NO was detected by Griess method. Results Salcatonin 1-8 U/ml significantly reduced NO synthesis and secretion from mouse peritoneal microphase in vitro . Conclusion The effects of Salcatonin on LPS induced release of NO from mouse peritoneal microphase in vitro may be one of anti osteoporosis mechanism of Salcatonin.; |
| Keywords: | Salcatonin Nitric oxide Macrophages |
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