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328例肾脏疾病患者的肾脏病理分析
引用本文:刘永梅,邹建洲,方艺,滕杰,傅辰生,刘春凤,刘红,丁小强. 328例肾脏疾病患者的肾脏病理分析[J]. 中国临床医学, 2006, 13(5): 801-803
作者姓名:刘永梅  邹建洲  方艺  滕杰  傅辰生  刘春凤  刘红  丁小强
作者单位:1. 安徽省巢湖市第一人民医院肾内科,安徽,巢湖,238000
2. 复旦大学附属中山医院肾内科,上海,200032
摘    要:目的:了解近年经皮肾活检肾脏疾病患者的病理类型分布及其与临床症状的关系。方法:回顾分析2004年6月~2005年6月间因肾脏疾病住院行肾活检的患者的临床病理特点。结果:328例肾脏疾病中,原发性肾小球疾病257例(78.4%)、小管间质疾病16例(4.9%)、继发性肾脏病55例(16.8%)。原发性肾小球疾病中IgA肾病137例,占53.3%;继发性肾小球肾炎中狼疮肾炎、紫癜性肾炎和高血压肾损害较多,分别占32.7%、27.3%和18.2%;小管间质疾病以急性间质性肾炎为多,占68.8%。IgA肾病主要表现为蛋白尿并血尿;膜性肾病、高血压肾病主要表现为单纯性蛋白尿。单纯血尿主要病理类型是IgA肾病;单纯蛋白尿主要病理类型是IgA肾病和轻微病变。蛋白尿并血尿主要病理类型是IgA肾病、轻微病变和狼疮性肾炎;大量蛋白尿主要病理类型是轻微病变、IgA肾病和膜性肾病。结论:本组资料显示原发性肾小球疾病仍为我国最常见的肾脏疾病,其中以IgA肾病最常见;小管间质疾病发病率有增高,继发性肾脏病以狼疮肾炎最常见,其它特殊肾脏病有增加。

关 键 词:肾脏疾病  临床表现  病理分型  肾活检

Clinicopathological Analysis of 328 Patients with Renal Disease
LIU Yongmei,ZOUJianzhou,FANG Yi, et al. Clinicopathological Analysis of 328 Patients with Renal Disease[J]. Chinese Journal Of Clinical Medicine, 2006, 13(5): 801-803
Authors:LIU Yongmei  ZOUJianzhou  FANG Yi   et al
Abstract:Objective:To investigate the pathological type and clinical manifestations of the renal diseases in patients undergoing percutaneous renal biopsy. Methods: From Jua 2004 to Jun. 2005, 328 patients were admitted into our hospital for renal diseases and accepted percutaneous renal biopsy. Clinical and renal pathological data were retrospectively studied. Results: In the all 328 cases, 78.4% patients suffered from primary glomerular nephritis(n=257), while 16.8% secondary glomerular ne-phritis(n=55) and 4.9% tubular intestitial diseases (n=16). Among the primary glomerular nephritis cases, there were 137 cases suffered from IgA nephropathy(55.3%). Lupus nephropathy(LN) (32.7%), hypertensive nephropathy(18. 2%) and Henoch-Schonlein purpura nephritis(HSPN)(27.3%) were major diseases in the secondary nephritis cases. In the tubular interstitial disease cases, 68.8% was acute interstitial nephrtis. Major clinical manifestations were proteinuria and hematuria in IgA nephropathy, while single proteinuria was major in membranous nephropathy and hypertensive nephropathy. In single hematuria patients, the major pathological diagnosis was IgA nephropathy. In single proteinuria cases, major pathological types were IgA nephropathy and minimal change nephropathy. In both proteinuria and hematuria cases, major pathological diagnosis were IgA nephropathy, minimal change nephropathy and LN. In gross proteinuria cases, major types were IgA nephropathy, minimal change nephropathy and membranous nephropathy. Conclusion: Primary glomerular diseases are the most common renal diseases in our country, in which IgA nephropathy may be the most common disease. The incidence of tubular interstitial disease increased. LN is the most common secondary glomerular diseases, and the most common clinical manifestations are proteinuria and hematuria.
Keywords:Kidney disease   Clinical manifestation   Pathological type   Renal biopsy
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