|
|||||
|
|
| 利多卡因减轻家兔心肌缺血-再灌注炎性损伤的研究 | |
| 引用本文： | 王友,王保生,林丽文,林娜,赵明耀.利多卡因减轻家兔心肌缺血-再灌注炎性损伤的研究[J].济宁医学院学报,2012,35(2):100-102. |
| 作者姓名： | 王友 王保生 林丽文 林娜 赵明耀 |
| 作者单位： | 1. 郑州大学基础医学院,河南郑州450052;济宁医学院基础医学与法医学院,山东济宁272067 2. 济宁医学院基础医学与法医学院,山东济宁,272067 3. 郑州大学基础医学院,河南郑州,450052 |
| 基金项目： | 济宁医学院2008年青年基金项目 |
| 摘 要： | 目的研究利多卡因的抗炎作用对心肌缺血-再灌注损伤的保护作用。方法 18只家兔随机分为3组(每组6只),假手术组、缺血-再灌注组和利多卡因组。监测家兔左室内压峰值(LVSP)、±dp/dtmax,测定血浆IL-6的水平,光镜观察心肌损伤及中性粒细胞的浸润程度。结果与缺血-再灌注组比较,利多卡因组LVSP及±dp/dtmax再灌注后的恢复率均高于缺血-再灌注组(P<0.01),血浆IL-6浓度明显低于缺血-再灌注组(P<0.01),心肌损伤及中性粒细胞浸润程度较轻。结论利多卡因可以提高心功能,抑制炎症反应,减轻家兔心肌缺血-再灌注损伤。 |
| 关 键 词： | 利多卡因 心肌缺血 再灌注损伤 白介素-6 |
The study of lidocaine on reducing inflammatory injury during myocardial ischemia/reperfusion injury in rats |
|
| Institution: | WANG You,WANG Bao-sheng,LIN Li-wen,et al(Basic School of Basic Medical Science,Zhengzhou University,Zhengzhou 450052,China) |
| Abstract: | Objective To investigate the protective effects of lidocaine on myocardial ischemia/reperfusion injury.Methods Eighteen rabbits were randomly divided into 3 groups(n= 6 each): sham-operated group,ischemia/reperfusion group and lidocaine group.Left ventricular systolic pressure(LVSP) and ±dp/dtmax of the heart were determined,and the level of plasma IL-6 was also measured.The degree of myocardial injury and neutrophils infiltration were observed with microscope.Results Compared with those of ischemia/reperfusion group,LVSP and ±dp/dtmax of the heart were better recovered during reperfusion in lidocaine groups(P<0.01).IL-6 concentration in plasma in lidocaine group were significantly lower than those in the ischemia/reperfusion group(P<0.01) and the degree of myocardial injury and neutrophils infiltration were alleviated.Conclusion The results demonstrate that lidocaine could improve cardiac function,inhibit inflammatory response and attenuate reperfusion injury in ischemic heart. |
| Keywords: | Lidocaine Myocardial ischemia Reperfusion injury IL-6 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |