原发韦氏环非霍奇金淋巴瘤50例临床特征和预后分析

目的 比较原发韦氏环非霍奇金淋巴瘤(WRNHL)常见病理类型的临床特征与预后差异.方法 对2008年1月至2013年12月收治的50例原发WRNHL患者的临床资料进行回顾性分析.Kaplan-Meier法计算生存率,用Log-rank法检验组间差异并行单因素预后分析.结果 原发WRNHL常见病理类型为弥漫大B细胞淋巴瘤(DLBCL)与结外鼻型NK/T细胞淋巴瘤(ENKTCL),其中DLBCL占56％(28/50),ENKTCL占34％(17/50).DLBCL的发病年龄明显大于ENKTCL,两者原发部位不同,50.0％(14/28)的DLBCL患者原发于扁桃体,88.2％(15/17)的ENKTCL原发于鼻咽部;DLBCL的近期疗效远优于ENKTCL, DLBCL的总生存率、无进展生存率均优于ENKTCL,差异均有统计学意义(x2=4.45,P=0.035;x2=6.47,P=0.011).结论 DLBCL和ENKTCL的临床特征不同,DLBCL的近期疗效及预后明显优于ENKTCL.

Clinical characteristics and prognosis analysis of 50 patients with primary Waldeyer's ring non-Hodgkin lymphoma

Objective To compare the clinicopathological characteristics and prognosis of primary Waldeyer's ring non-Hodgkin lymphoma.Methods From Jan 2008 to Dcc 2013, 50 patients with primary Waldeyer's ring non-Hodgkin lymphoma were retrospectively analyzed.Kaplan-Meier method was used for survival analysis.Log-rank method was used for univariate analysis.Results Waldeyer's ring diffuse large B-cell lymphoma (DLBCL) and extranodal nasal-type NK/T-cell lymphoma (ENKTCL) were the common pathological types of primary Waldeyer's ring non-Hodgkin lymphoma accounting for 56 ％ (28/50) DLBCL and 34 ％ (17/50) ENKTCL, respectively.The age at onset of ENKTCL patients was younger than that of DLBCL patients.Two groups had different primary sites, including 50.0 ％ (14/28) of DLBCL with tonsillar disease and 88.2 ％ (15/17) of ENKTCL with nasopharynx disease.The short phase effect of DLBCL group was higher than that of ENKTCL group.The overall survival (OS) and progression-free survival (PFS) rates had significant differences between DLBCL and ENKTCL (x2 =4.45, P =0.035;x2=6.47, P =0.011).Conclusion DLBCL and ENKTCL are different in clinical characteristics.The short phase effect and prognosis of DLBCL are obviously better than those of the ENKTCL.