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| 复方利多卡因乳膏体外透皮吸收实验 | |
| 引用本文： | 舒成仁,葛苗苗,黄露,吴海燕,黎维勇.复方利多卡因乳膏体外透皮吸收实验[J].医药导报,2011,30(8):997-999. |
| 作者姓名： | 舒成仁 葛苗苗 黄露 吴海燕 黎维勇 |
| 作者单位： | 1. 湖北省黄石市中心医院药剂科,435000 2. 华中科技大学同济医学院附属协和医院药剂科,武汉,430022 3. 湖北省医药工业研究院,武汉,430061 |
| 摘 要： | 目的比较复方利多卡因乳膏实验制剂和市售参比制剂的透皮吸收效果，并考察复方利多卡因乳膏实验品存放不同时间的透皮吸收能力。方法以Franz扩散池和体外大鼠皮肤进行体外渗透实验，采用高效液相色谱法同时测定利多卡因和丙胺卡因的药物浓度，计算累积透皮吸收量，评价制剂的体外透皮吸收效果。结果两组制剂8 h内不同时段透皮吸收累积量差异无统计学意义。有效期内不同存放时间实验制剂各批的透皮吸收累积量和释药速率差异无统计学意义。结论实验制剂和参比制剂的透皮吸收能力一致，在有效期内，不同存放时间的实验制剂透皮吸收能力基本一致。 |
| 关 键 词： | 利多卡因 丙胺卡因 乳膏 色谱法 高效液相 透皮吸收 |
Percutaneous Absorption of the Compound Lidocaine Cream in Vitro |
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| SHU Cheng-ren,GE Miao-miao,HUANG Lu,WU Hai-yan,LI Wei-yong.Percutaneous Absorption of the Compound Lidocaine Cream in Vitro[J].Herald of Medicine,2011,30(8):997-999. | |
| Authors: | SHU Cheng-ren GE Miao-miao HUANG Lu WU Hai-yan LI Wei-yong |
| Institution: | SHU Cheng-ren1,GE Miao-miao2,HUANG Lu2,WU Hai-yan3,LI Wei-yong2(1.Department of Pharmacy,Huangshi Central Hospital,Hubei Province,Huangshi 435000,China 2.Department of Pharmacy,Union Hospital Affliated with Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China,3.Hubei Provincial Institute Co.Ltd.Pharmaceutical Industry,Wuhan 430061,China) |
| Abstract: | Objective To compare the percutaneous absorbency of the compound lidocaine cream between the lab made and commercially available one during different periods of storage.Methods The permeation of the cream was studied on rat skin with Franz diffusing cell.Lidocaine and prilocaine was quantified by HPLC.The percutaneous absorbency in vitro was evaluated by transdermal absorption accumulation of lidocaine and prilocaine.Results There were no significant difference in the transdermal absorption accumulation bet... |
| Keywords: | Lidocaine Prilocaine Cream HPLC Percutaneous absorption |
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