腹腔复苏对失血性休克家兔肝脏功能的影响

目的 观察腹腔复苏对失血性休克家兔肝脏功能的影响。方法 21 只雄性家兔随机分为3组，正常对照组 (A组) 、常规静脉复苏组（B组）、腹腔复苏组（C组）。B组与C组于10min 内使MAP降至40mmHg。通过放血或回输血液维持40mmHg 水平60min后，在20min内静脉回输放出的血液和两倍于放血量的复方乳酸钠进行液体复苏，并于血液和液体复苏的同时，C组腹腔内注射120mL临床用透析液，而A组和B组腹腔注入等量生理盐水对照。观察休克前、休克后60min、液体复苏后60min和180 min的ALT和AST活性。复苏3h后，取肝组织测定干湿重比、MDA、SOD，观察形态学变化。结果 C组ALT和AST值均低于B组( P<0.05 )，MDA与SOD活性分别低于和高于B组 (P<0.05)。C组组织的干湿重比值高于B组(P<0.05)；B组形态学损伤较C组更明显。并且与正常对照组组相比结果相近。结论 腹腔复苏对失血性休克家兔足量液体复苏后的肝脏功能可能有改善作用。[关键词] 失血性休克 ；腹腔复苏；肝脏功能

Effects of peritoneal resuscitation on hepatic function in rabbits with hemorrhagic shock

Objective To investigate the effects of peritoneal resuscitation on liver function in rabbits with hemorrhagic shock. Methods Twenty-one male rabbits were randomly divided into 3 groups: no hemorrhagic shock group(Group A),conventional resuscitation group(Group B),and peritoneal resuscitation group(Group C).Rabbits in Group B and C were exsanguinated until mean blood pressure(MAP) reached 40 mmHg within 10 minutes.MAP was kept at 40 mmHg for 60 minutes prior to resuscitation with shed blood plus double hemo...