西吡氯铵含漱液对牙龈炎菌斑形成的预防作用

目的 :目的 :观察 0 .1%西吡氯铵含漱液对单纯性牙龈炎患者牙菌斑形成的抑制作用。方法 :单纯性牙龈炎 48例 ,随机分为 2组 ,应用双盲法分别给予 0 .1%西吡氯铵含漱液 (实验组 )或爱诺天健含漱液 (对照组 )。(主要成分亦为 0 .1%西吡萌铵 )。每天 5次 ,晨起、睡前、饭后各一次 ,每次含 15ml,持续漱口 60s ,漱口后 1h内禁饮食 ,7d为一疗程。就诊当天 ( 1d)、4d、8d按照Quigley -Hein指数 (Turesky改良 )测定菌斑指数。第 1天行左侧半口上下颌牙齿洁治 ,第 8天行右侧半口上下颌牙齿洁治。结果 :实验组和对照组 ,每组各 2 4例 ,年龄、性别、吸烟史分布无组间差异 (P >0 .0 5 ) ,基线检查菌斑指数无组间差异 (P >0 .0 5 ) ;中期检查实验组和对照组菌斑指数显著低于基线值 (P <0 .0 5 ) ,菌斑指数差值组间比较无显著差异 (P >0 .0 5 ) ;终点检查实验组和对照组菌斑指数显著低于中期检查值 (P <0 .0 5 ) ,菌斑指数差值组间比较无显著差异 (P >0 .0 5 )。中期和终点检查左半口菌斑指数测量值与右半口测量值比较均显著减少 (P <0 .0 5 )。结论 :0 .1%西吡氯铵含漱液可预防单纯性牙龈炎患者牙菌斑的形成。

The effect of mouth rinse containing 0.1% cetylpyridinium chloride in the inhibition of dental plague formation in patients with simple gingivitis

Objective:To observe the effects of mouth rinse containing 0.1 % cetylpyridinium chloride in the inhibition of dental plague formation in patients with simple gingivitis. Method:48 cases of simple gingivitis were enrolled and divided into two groups. Random and double bland method was applied to administer 0.1 % cetylpyridinium chloride (tested group) or Ainotianjian mouth rinse(another product also containing 0.1 % cetylpyridinium chloride,control group) to the patients. The mouth rinses were used by the patients for 7 days and 5 times each day (after getting up and each meal, and before going to bed), each time 15ml mouth rinse was used for 1 minute. Plague Index (PI, Quigley-Hein Index modified by Turesky) was measured before treatment, on day 4 and 8 respectively. Periodontal scaling was performed on the left side on day 1 before treatment and on the right side on day 8 after treatment. Result:The distribution of age, sex and smoking in the tested 24 cases was not significantly different from that of the 24 controls (P> 0.05 ). Before treatment, no statistic difference was found in PI between the two groups (P> 0.05 ). On day 4, PI in both groups was significantly lower than that on day 1 (P< 0.05 ) and there was no statistic difference in the decrease of PI between the two groups(P> 0.05 ). On day 8, PI was significantly lower than that on day 4(P< 0.05 ) in both groups and there was no statistic difference in the decrease of PI between the two groups(P> 0.05 ). On day 4 and on day 8 PI of left teeth was decreased more than that of right teeth(P< 0.05 ). Conclusion: 0.1 % cetylpyridinium chloride is effective in the inhibition of dental plague formation in patients with simple gingivitis.