| 血小板活化因子受体拮抗剂-BN 52021对内毒素引起大鼠急性肺动脉高压影响的观察 |
| |
| 引用本文： | 汪金锋,江凌,张劲农. 血小板活化因子受体拮抗剂-BN 52021对内毒素引起大鼠急性肺动脉高压影响的观察[J]. 实用心脑肺血管病杂志, 2002, 10(5): 259-261 |
| |
| 作者姓名： | 汪金锋 江凌 张劲农 |
| |
| 作者单位： | 430022,武汉华中科技大学同济医学院附属协和医院 |
| |
| 摘 要： | ![]()
目的：探讨特异性血小板活化因子（PAF）受体拮抗剂－BN52021对内毒素引起的肺动脉高压的影响。方法：Wistar大鼠静脉注入内毒素引起急性肺动脉高压；应用BN52021预处理：观察BN52021对经内毒素处理大鼠的血液动力学、血浆肿瘤坏死因子α（TNF－α）、血栓素B2（TXB2）及动脉血气变化的影响。结果：BN52021可部分抑制内毒素引起的急性肺动脉高压；降低血浆TNF－α和TXB2的含量，提高动脉血氧分压。结论：BN52021能减轻内毒素引起的肺伤；降低内毒素引起的大鼠肺动脉高压。
|
| 关 键 词： | 血小板活化因子受体拮抗剂 BN52021 内毒素 肺动脉高压 血浆肿瘤坏死因子 血栓素B2 |
| 修稿时间： | 2002-05-08 |
Effect of special platelet-activating factor receptor antagonist(BN 52021) on endotoxin-induced acute pulmonary hypertension in wistar rats |
| |
| Wang Jinfeng,Jiang Ling,Zhang Jinnong The Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan. Effect of special platelet-activating factor receptor antagonist(BN 52021) on endotoxin-induced acute pulmonary hypertension in wistar rats[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2002, 10(5): 259-261 |
| |
| Authors: | Wang Jinfeng Jiang Ling Zhang Jinnong The Union Hospital Tongji Medical College Huazhong University of Science Technology Wuhan |
| |
| Affiliation: | Wang Jinfeng,Jiang Ling,Zhang Jinnong The Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 420022 |
| |
| Abstract: | ![]()
|
| |
| Keywords: | Endotoxin Pulmonary hypertension Receptor Platelet Activating factor BN 52021 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
