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Discitis and sacroiliitis diagnosed 15 years after iatrogenic Mycobacterium xenopi inoculation
Authors:Jean-Hugues Salmon  Guillaume Direz  Jean-Marc Ziza  Nicole Desplaces  Pascal Brochot  Jean-Paul Eschard
Affiliation:1. Service de rhumatologie, CHU de Reims, 45, rue Cognac-Jay, 51100 Reims, France;2. Service de médecine interne et rhumatologie, groupe hospitalier Diaconesses Croix Saint-Simon, 125, rue d’Avron, 75020 Paris, France;3. Laboratoire de biologie médicale, groupe hospitalier Diaconesses Croix Saint-Simon, 125, rue d’Avron, 75020 Paris, France;1. Korea Institute of Drug Safety and Risk Management (KIDS), Boryung Bldg, 136 Changgyeonggung-ro, Jongno-Gu, Seoul 110-750, South Korea;2. Division of Epidemic Intelligence Service, Korea Centers for Disease Control and Prevention (KCDC), Osong-eup, Cheongwon-gun, Chungcheongbuk-do, South Korea;3. Department of Preventive Medicine, Dongguk University College of Medicine, Gyeongju-si, Gyeongsangbuk-do, South Korea;4. Division of Tuberculosis and Bacterial Respiratory Infection, Center for Infectious Diseases, Korea National Institute of Health (KNIH), Osong-eup, Cheongwon-gun, Chungcheongbuk-do, South Korea;5. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea;1. Chemical Engineering Department, University of Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain;2. Chemical Engineering Program – COPPE, UFRJ, 21941-972 Rio de Janeiro, Brazil;1. Department of Respiratory Diseases, San Camillo-Forlanini Hospital, Rome, Italy;2. Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;3. Department of Cardiovascular, Respiratory, Nephrologic, Anesthesiologic, and Geriatric Sciences, University of Rome Sapienza, Rome, Italy;3. INSERM, U1229, RMeS “Regenerative Medicine and Skeleton,” STEP team “Skeletal Physiopathology and Joint Regenerative Medicine,” Nantes F-44042, France;4. Université de Nantes, UMR-S 1229, RMeS, UFR Odontologie, Nantes F-44042, France;5. CHU Nantes, PHU 4 OTONN, Nantes F-44042, France
Abstract:A patient was diagnosed with discitis and sacroiliitis due to Mycobacterium xenopi. He had a history of percutaneous nucleotomy performed 15 years earlier (in 1992) at the Clinique du Sport, Paris, France, during an outbreak of nosocomial M. xenopi infection at that institution. In 1997, magnetic resonance imaging performed as part of the routine follow-up program for patients who had surgery at the Clinique du Sport during the outbreak was not interpreted as indicating discitis; this assessment was confirmed by our review of the images. Bone and joint infections due to atypical mycobacteria are rare and can develop very slowly. To our knowledge, this is the first reported case of M. xenopi discitis with secondary extension to the sacroiliac joint in an immunocompetent patient.
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