Identification and screening of carbapenemase-producing Enterobacteriaceae |
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| Authors: | P Nordmann M Gniadkowski CG Giske L Poirel N Woodford V Miriagou |
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| Institution: | 1. Service de Bactériologie-Virologie, INSERM U914 ‘Emerging Resistance to Antibiotics'', Hôpital de Bicětre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicětre, France;2. Department of Molecular Microbiology National Medicine Institute, Warsaw, Poland;3. Clinical Microbiology MTC, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden;4. Antibiotic Resistance Monitoring and Reference Laboratory Health Protection Agency, London, UK;5. Laboratory of Bacteriology, Hellenic Pasteur Institute, Athens, Greece |
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| Abstract: | Carbapenem-hydrolysing β-lactamases are the most powerful β-lactamases, being able to hydrolyse almost all β-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant. Detection of infected patients and of carriers are the two main approaches for prevention of their spread. Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media. |
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| Keywords: | Antibiotic carbapenem Gram-negatives resistance β-lactams |
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