Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010 |
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| Authors: | M. Colafigli C. Torti E.M. Trecarichi L. Albini A. Rosi V. Micheli N. Manca G. Penco B. Bruzzone G. Punzi P. Corsi G. Parruti P. Bagnarelli L. Monno A. Gonnelli R. Cauda S. Di Giambenedetto |
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| Affiliation: | 1. Institute of Clinical Infectious Diseases, Catholic University of S. Heart, Rome;2. Institute of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy;3. Department of Biotechnology, University of Siena, Siena, Italy;4. Laboratory of Microbiology, Hospital L. Sacco, Milan, Italy;5. Department of Virology, University of Brescia, Brescia, Italy;6. Infectious Diseases Department, E.O. Ospedali Galliera, Genoa, Italy;7. Laboratory of Hygene, S. Martino Hospital, Genoa, Italy;8. Clinical Infectious Diseases, University of Bari, Bari, Italy;9. Division of Infectious Diseases, Careggi Hospital, Florence, Italy;10. Clinical Infectious Diseases, Hospital of Pescara, Pescara, Italy;11. Department of Biomedical Sciences and Public Health, Laboratory of Virology, Università Politecnica delle Marche, Ancona, Italy;12. Infectious Diseases and Liver Unit, Policlinic ‘Santa Maria alle Scotte’, Siena, Italy |
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| Abstract: | ![]()
Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviralna?ve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. |
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| Keywords: | Antiretroviral therapy chronic HIV infection recent HIV infection resistance epidemiology transmitted resistance |
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