| 氟啶酸在健康人体内药动学研究 |
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| 引用本文： | 罗顺德 蔡鸿生. 氟啶酸在健康人体内药动学研究[J]. 中国医院药学杂志, 1991, 11(1): 13-15 |
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| 作者姓名： | 罗顺德 蔡鸿生 |
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| 作者单位： | 湖北医学院临床药学研究室 430060(罗顺德，蔡鸿生，张先州)，湖北医学院临床药学研究室 430060(尹武华) |
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| 摘 要： | 本文用尿药浓度法,研究了6名志愿者单剂量口服氟啶酸片、胶囊剂后的药物动力学。结果表明,氟啶酸片剂,胶囊剂具有相同的药物学特征及生物等效性。其药动学参数分别是:k(hr~(-1)):0.1048、0.1039;t1/2(hr):6.92,7.08;Au~(0-42)(mg):460.78,462.51;排泄率:76.80%,77.09%。氟啶酸片的相对生物利用度为99.62%。
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| 关 键 词： | 氟啶酸 尿药浓度 药动学 |
Pharmacokinetic Study on Enoxacin in Healthy Chinese Volunteers |
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| Luo Shun-de,Cai Hong-Sheng,Zhang Zhuang,Li Da-Juen. Pharmacokinetic Study on Enoxacin in Healthy Chinese Volunteers[J]. Chinese Journal of Hospital Pharmacy, 1991, 11(1): 13-15 |
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| Authors: | Luo Shun-de Cai Hong-Sheng Zhang Zhuang Li Da-Juen |
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| Affiliation: | Luo Shun-de,Cai Hong-Sheng,Zhang Zhuang,Li Da-Juen Department of Clinical Pharmaceutical Research,Hubei Medical College,wuchang 430060 |
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| Abstract: | The concentration of enoxacin in urine of six healthy chinese volunteers wasdetermined after the tablet or the capsule was orally given by single-dose. thepharmacokinetic parameters were calculated from the urine drug concentration cur-ves the result showed that the parameters of enoxacin tablet and capsule were K(hr~(-1)) 0. 1048,0.1039; t1/2(hr)6.92, 7.08; Au~(0-24)(mg)460. 78,462.51 and eliminative ra-te(cumulative)6.80%,77.09% respectively. the relative bioavailability of the tabletwas 99.6% |
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| Keywords: | Enoxacin Drug levels in urine pharmaeokineties |
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