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| 实验性高脂血症对阿霉素肾病鼠的加速肾毒作用 | |
| 引用本文： | 姚勇,徐国宾,张英,杨霁云,朱丽华. 实验性高脂血症对阿霉素肾病鼠的加速肾毒作用[J]. 北京大学学报(医学版), 1997, 0(2) |
| 作者姓名： | 姚勇 徐国宾 张英 杨霁云 朱丽华 |
| 作者单位： | 北京医科大学第一医院儿科(姚勇，张英，杨霁云)，北京医科大学第一医院检验科!100034(徐国宾，朱丽华) |
| 摘 要： | 目的：观察实验性高脂血症对肾病鼠的肾毒性作用。方法：阿霉素肾病鼠随机分为两组，分别饲以高脂饲料和普通饲料，测定其血脂，肾功能、尿蛋白和肾皮质SOD，并进行肾组织学观察。结果：肾病高脂饮食组与肾病对照组比较，2周后血胆固醇、甘油三酯明显升高，8周后肌酐清除率和肾皮质SOD水平明显下降。结论：过量的脂质可加速肾病时肾损伤且与自由基代谢失衡有关。 |
| 关 键 词： | 高脂血症 肾变病综合征 阿霉素／毒性 |
EXACERBATION OF NEPHROTOXICITY IN ADRIAMYCIN-INDUCED NEPHROTIC RATS BY EXPERIMENTAL HYPERLIPIDEMIA |
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| YAO Yong, XU Guobin, ZHANG Ying, YANG Jiyun, ZHU Lihua.. EXACERBATION OF NEPHROTOXICITY IN ADRIAMYCIN-INDUCED NEPHROTIC RATS BY EXPERIMENTAL HYPERLIPIDEMIA[J]. Journal of Peking University. Health sciences, 1997, 0(2) | |
| Authors: | YAO Yong XU Guobin ZHANG Ying YANG Jiyun ZHU Lihua. |
| Abstract: | Objective:The effect of experimental hyperlipidemia on nephrotoxicity of nephrotic rats wasstudied. Methods: Adriamycin-induced nephrotic rats were randomized into 2 groups, feeding with hyperlipidic diet or general diet. The plasma lipids, renal function, protein in urine and SOD in renal cortex were measured. The renal morphological change was observed. Results: In hyperlipidic diet group,the plasma cholesterol and triglyceride elevated significantly after 2 weeks (p<0. 05), the creatinineclearance rate and the level of SOD in renal cortex were decreased significantly after 8 weeks (p<0. 05).Conclusion: Overload of lipid can induce the progression of renal injury in nephrotic syndrome which isalso related with the abnormal metabolism of oxygenic free-radical. |
| Keywords: | Hyperlipidemia Nephrotic Syndrome Doxorubicin/tox |
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