心肌肌钙蛋白I与冠心病远期心脏事件的关系

目的探讨冠心病患者血清心肌肌钙蛋白I(cTnI)水平与远期心脏事件的相关性。方法测定96例冠心病患者的血清cTnI、肌酸激酶同工酶(CK-MB),根据cTnI的值分为二组,根据临床资料、冠状动脉造影结果,随访患者远期心脏事件,分析cTnI与心脏事件的相关因素及它们的关系。结果96例患者中有34例cTnI升高,3例肌酸激酶同工酶轻度升高,cTnI升高与心电图出现异常Q波、ST段改变关系有统计学意义(P<0.01);92例近期存活者中87例进行了远期随访,随访时间为(24±8)个月,共有21例患者发生心脏事件,其发生与cTnI升高关系有统计学意义(P<0.05)。结论血清cTnI是心肌损伤敏感而特异性的指标,是冠心病患者远期心脏事件的独立预测因子。

Relationship of Cardiac Troponin I With Late Heart Events of Patients with Coronary Heart Disease

Objective To investigate the correlation of serum cardiac troponin I (cTnI) and the late heart events of patients with coronary heart disease (CHD).Methods Serum cTnI and Creatine kinase isoenzyme MB of 96 patients with CHD were measured.These Patients were divided into two groups according to levels of cTnI.Based on e general clinical data and,results of coronary arteriography and follow up vist of late heart event of these patients,The correlative factors of cTnI level and heart events and their relationship were analyzed.Results Among 96 patients,34 patients has increased level of cTnI,3 patients has light increased level of creatinkinase isozyme,there is statistical significance between high cTnI and abnormal Q wave or changes of ST segment deviation(P<0.01).Among 92 survival cases,87 patients have follow up visit about 24 monthes,in which there are 21 patients have heat event.The relationship between its occurrence and the increased cTnI is also have statistical significance (P<0.05).Conclusion Serum cTnI is a higher sensitive and specific marker for myocardial damage,which can be an independent indicator of late heart events in patients with CHD.