幽门螺杆菌感染与脑梗死患者同型半胱氨酸的关系

目的:研究幽门螺杆菌(Hp)感染与初发急性脑梗死的关系及对急性脑梗死患者血清同型半胱氨酸(Hcy)的影响。方法:采用生物微矩阵(芯片)分析技术测定初发急性脑梗死(85例)血清Hp-IgG、Hp-CagA-IgG和Hcy,并与对照组(40例)比较。结果:①急性脑梗死组Hp-IgG阳性率及Hp-CagA-IgG阳性率高于对照组(P<0.05)。②Hp-IgG阳性组与阴性组的血清Hcy水平无明显差异(P>0.05),而Hp-CagA-IgG阳性组患者Hcy水平高于Hp-CagA-IgG阴性组(P<0.05)。结论:Hp感染与脑梗死发病相关,可能是脑梗死的危险因素;CagA阳性Hp感染可能通过升高血Hcy水平而增加脑梗死的风险。

Association of Helicobacter pylori infection and serum homocysteine level in patients with cerebral infarction

Objective: To investigate the association of Helicobacter pylori infection and serum homocysteine(Hcy) levels with acute cerebral infarction. Methods: Serum Hp-IgG,Hp-CagA-IgG and Hcy were detected by biological micro-array analysis system in 85 patients with acute cerebral infarction and 40 healthy subjects(control group). Results: The positive rates of Hp-IgG and Hp-CagA-IgG significantly increased in cerebral infarction group compared with controls(P<0.05).There were significant differences in serum Hcy level between Hp-CagA-IgG positive and negative patients(P<0.05),but not between Hp-IgG positive and negative patients(P>0.05). Conclusion: CagA-positive Hp infection may increase the risk of cerebral infarction,which might be associated with the increased serum homocysteine level.