血清SOD、NGAL及KIM-1水平对2型糖尿病早期肾损伤的诊断价值

目的 测定2型糖尿病患者血清超氧化物歧化酶(SOD)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)及肾损伤分子-1(KIM-1)水平,并分析其诊断价值.方法 选取2型糖尿病患者212例,根据尿微量白蛋白/尿肌酐比值(ACR)分为阴性组(n=163)和阳性组(n=49),另选择同期进行体检的健康人118例作为对照组,测定...

The diagnostic value of serum SOD,NGAL and KIM-1 levels in early kidney injury of type-2 diabetes

Obejctive To determine the level of serum superoxide dismutase(SOD),neutrophil gelatinase-related lipocalin(NGAL)and Kindney Injury Molecule 1(KIM-1)in patients with type 2 diabetes,and to analyze its diagnostic value.Methods A total of 212 patients with type 2 diabetes were selected and divided into a negative group(n=163)and a positive group(n=49)according to urine microalbumin/urine creatinine ratio(ACR),and 118 healthy people who underwent health examinations at the same time were selected as health control.Serum SOD,NGAL and KIM-1 levels were measured,and statistical analysis was performed to calculate the diagnostic value of SOD and NGAL alone or in combination for early renal injury in diabetes.Results The SOD level in the negative group was significantly higher than that in control group218(176~234)]U/mL vs233(192~276)]U/mL,P<0.001,and the SOD level in the positive group was signally lower than that in the negative group172(142~215)]U/mL vs218(176~234)]U/mL,P<0.01;There was no significant difference in the NGAL level between the negative group and control group46.2(22.3~68.1)]mg/L vs39.4(19.8~47.3)]mg/L,P>0.05,The NGAL level in the positive group was notably lower than that in the negative group98.6(56.4~130.0)]mg/L vs46.2(22.3~68.1)]mg/L,P<0.001;the KIM-1 level in the negative group was markedly higher than that in the control group43.0(35.9~51.4)]ng/L vs33.2(28.1~37.9)]ng/L,P<0.05,the KIM-1 level in the positive group was prominently lower than that in the negative group77.6(54.2~93.8)]ng/L vs43.0(35.9~51.4)]ng/L,P<0.001.The detection rate of SOD,NGAL and KIM-1 for early diabetic kidney injury was 73.47%,85.71%and 87.76%respectively,and the area under the ROC curve was 0.737,0.816 and 0.876,respectively.The positive detection rate was 95.92%after the three were applied in combination,where the area under the ROC curve is 0.957.Conclusion With the decrease of serum SOD level and the increase of NGAL and KIM-1 level,the combined detection of these three levels is helpful for the detection and early intervention of renal injury in early diabetic stage.