长期低剂量克拉霉素治疗慢性鼻窦炎

目的：观察长期低剂量克拉霉素治疗慢性鼻窦炎的疗效。方法：2002年4月至2003年1月我们用低剂量克拉霉素治疗63例慢性鼻窦炎，检测治疗前后糖精传输时间，观察治疗3、6个月后患者症状、鼻内镜检查、鼻窦CT检查及鼻窦黏膜病理的改善情况。结果：治疗3、6个月后鼻腔通气改善分别为66.7%、73.0%、；鼻涕量减少65.1%、74.6%；头痛减轻73.5%、85.3%；嗅觉改善30.0%、35.0%；鼻内镜检查好转55.8%、69.2%；CT扫描结果较用药前改善61.4%、68.4%；病理检查示鼻窦黏膜炎症减轻38.5%、61.5%。治疗前平均ST为(35.5±6.3)min，用药3个月后为(27.8±6.6)min，6个月后为(19.7±7.1)min。结论：长期低剂量克拉霉素治疗慢性鼻窦炎效果较好。

Assessment of long-term low-dose clarithromycin for chronic sinusitis

Objective: To explore the curative effect of long term low dose clarithromycin for chronic sinusitis. Methods: Long term low dose clarithromycin was administered in 63 patients with chronic sinusitis from April 2002 to January 2003. The symptoms, nasal endoscopic examination,CT scan of nasal sinuses and the pathology of sinus mucosa were assessed 3 and 6 months later, and the saccharine transit time (ST) was measured to assess the transporting function of nasal mucosa before and after treatment. Results: The 3 and 6 month response rates of stuffy nose, runny nose, headache, sense of smell, nasal endoscopy, CT scan and pathology were 66.7% and 73.0 %, 65.1% and 74.6%, 73.5% and 85.3%, 30.0% and 35.0%, 55.8% and 69.2%, 61.4% and 68.4%, 38.5% and 61.5% respectively. The mean ST was 35.5±6.3 minutes before treatment, and 27.8±6.6 minutes and 19.7±7.1 minutes at the 3rd and 6th months. Conclusion: Low dose clarithromycin for a long term has a salutary effect on chronic sinusitis patients.