天麻素离子敏感鼻用原位凝胶体外释药研究

目的:研究天麻素离子敏感鼻用原位凝胶的体外释药特性与机制。方法:采用扩散池法考察天麻素鼻用原位凝胶的释药规律,并用无膜溶出法研究其释放机制。根据鼻腔释药环境的特点,设计了动态扩散池法,考察该原位凝胶的黏附性对释药的影响。结果:天麻素鼻用原位凝胶的释药符合一级释放模型,其溶蚀度较小且与释放度无明显相关性。与天麻素溶液剂相比,其鼻用原位凝胶能延长释药时间,增加释药量。结论:天麻素离子敏感鼻用原位凝胶主要通过扩散而非溶蚀方式释药,在鼻腔内的释药量可因其黏附性显著增加。

Study on drug release of gastrodin ion-activated nasal in situ gel in vitro

Objective:To study on the drug release characteristics and mechanism of gastrodin ion-activated nasal in situ gel in vitro.Method:Regularity and mechanism of the drug release of gastrodin nasal in situ gel were studied by using the diffusion cell model and the membrane-less dissolution model,respectively.A novel kinesis diffusion cell model was designed according to the characteristics of release environment of nasal cavity.It was used to investigate the effect of adhesiveness on the release of the in situ gel.Result:Drug release of gastrodin nasal in situ gel followed the one order release model.Erosion rate of the gel was low and not linearly correlated with the release rate.Compared with gastrodin solution,the nasal in situ gel could increase release time and release amount.Conclusion:Gastrodin in the nasal in situ gel is released mainly by diffusion rather than erosion.Release amount of the in situ gel in nasal cavity may be obviously increased because of its adhesiveness.