| 川芎嗪对大鼠蛛网膜下腔出血后血管痉挛的防治研究 |
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| 引用本文： | 申艳莉,罗祖明.川芎嗪对大鼠蛛网膜下腔出血后血管痉挛的防治研究[J].四川医学,2002,23(6):557-558. |
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| 作者姓名： | 申艳莉 罗祖明 |
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| 作者单位： | 四川大学华西医院,四川,成都,610041 |
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| 摘 要： | 目的 探讨川芎嗪对蛛网膜下腔出血（SAH）后血管痉挛（CVS）的防治作用。方法 40只SD大鼠随机分为A：假手术组（空白组）；B：痉挛组；C：川芎嗪组；D：尼莫地平组。经自体血红蛋白局部注射法建立SAH后CVS模型。用动态图像分析法监测基底动脉血管直径变化，并测定各组大鼠血浆脂质过氧化物（LPO）的体内代谢产物丙二醛（MDA）水平。结果 B组血管直径较A组缩小（P＜0．001）；C组、D组血管与B相比直径增大（P＜0．001）；MDA水平C组比其余三组降低，其差异有统计学意义（P＜0．001）。结论 川芎嗪对SAH后CVS有防治作用。
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| 关 键 词： | 川芎嗪 大鼠 蛛网膜下腔出血 血管痉挛 防治 研究 |
| 文章编号： | 1004-0501(2002)06-0557-02 |
| 修稿时间： | 2002年4月27日 |
Therapeutic effect of Ligustrazinge on cerebra vascular spasm after subarachnoid hemorrhage |
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| Sheng Yanli,Luo Zuming.West China Hospital,Sichuan University,Chengdu,Sichuan.Therapeutic effect of Ligustrazinge on cerebra vascular spasm after subarachnoid hemorrhage[J].Sichuan Medical Journal,2002,23(6):557-558. |
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| Authors: | Sheng Yanli Luo ZumingWest China Hospital Sichuan University Chengdu Sichuan |
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| Institution: | Sheng Yanli,Luo Zuming.West China Hospital,Sichuan University,Chengdu,Sichuan 610041 |
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| Abstract: | Objective To assess the effecacy of Ligustrazinge hydrochloride for cerebra vascular spasm(CVS) after subarachnoid hemorrhage(SAH).Methods Forty rats were divided randomly into 4 groups ,(a)control group;(b)cerebra vasospasms group;(c)Ligustrazine group;(d)Nimotop group.Basilar artery diameter change was monitored by stereotypes microscopy after injecting hemolysate topically,and plasma lipid peroxide(LPO)was determined.Results Compared with that in cerebra vasospasms group,the artery diameter in Ligustrazine group dilated significantly ( P <0.001).The degree of the dilatation in Ligustrazine group is same to that in Nimotop group.Conclusion Ligustrazine is effetive in preventing CVS after SAH. |
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| Keywords: | Ligustrazine Cerebra vascular spasm Subarachnoid hemorrhage Lipid peroxide |
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