冠心病患者分泌型磷脂酶A2与高敏C反应蛋白、肌酸激酶的检测及其临床价值

【目的】观察分泌型磷脂酶A2(sPLA2)与高敏C反应蛋白(hs-CRP)、肌酸激酶(CK-MB)在冠心病中的变化情况并分析其相关性,评价其在冠心病诊疗方面的价值。【方法】测定28例稳定型心绞痛(SA)、54例不稳定型心绞痛(UA)、22例急性心梗患者(AMI)、20例非冠心病患者(NS)血浆sPLA2、hs-CRP和CK-MB的浓度变化情况,并进行统计学分析。【结果】sPLA2和hs-CRP在AMI组升高最明显,UA组和SA组次之;CK-MB在AMI组升高最明显,而SA组以及UA组两组间比较无显著性差异,但较对照组有显著升高。【结论】冠心病患者sPLA2与hs-CRP、CK-MB呈现正相关,三者显著升高可辅助临床诊断急性心梗、sPLA2和hs-CRP升高可用以鉴别SA和UA。

Relationship Between sPLA2,hs-CRP and CK-MB in Coronary Heart Disease and Its Clinical Value

[Objective] To observe the changes of serum secretary type II phospholipase(sPLA2),high sensitive C-reactive protein(hs-CRP)and MB isoenzyme of creatine kinase(CK-MB)in patients with coronary heart disease and to analyze their correlation.[Methods] Serum levels of sPLA2,hs-CRP and CK-MB were detected in 28 patients with stable angina(SA),54 patients with unstable angina(UA),22 patients with acute myocardial infarction(AMI)and 20 patients with normal coronary artery(NS).[Results] Serum levels of sPLA2 and hs-CRP increased significantly in AMI group compared with those in SA and UA groups.CK-MB increased significantly in AMI group,and it was higher than that in both SA and UA groups,which there was no statistical significant difference between them.[Conclusion] sPLA2,hs-CRP and CK-MB present positive correlation.The obviously increasing of sPLA2,hs-CRP and CK-MB is useful for the diagnosis of AMI,and the increasing of sPLA2 and hs-CRP is useful to distinguish SA and UA.