C 反应蛋白与缺血性卒中 NIHSS 评分相关性研究

目的：探讨缺血性脑卒中患者C反应蛋白与患者入院及发病3周时NIHSS评分的关系，为患者的病情评估与预后评估提供参考证据。方法收集脑梗死住院患者为研究对象。采用调查问卷的方法，收集研究对象的基本研究信息，入院24 h内完成超敏C反应蛋白的检测，并记录患者入院时及发病3周时的NIHSS评分。结果入院时，重症组患者的C反应蛋白水平要高于轻型组患者（5.59±3.72）vs（4.30±2.34）]；入院3周时，神经系统预后不良组的C反应蛋白水平也比预后良好组的浓度高（7.20±4.01） vs（2.97±1.65）]，差异均具有统计学意义。多元logistic回归结果显示，C反应蛋白水平升高，患者发生重型卒中的风险升高1.56倍，95％ C I为1.13～2.18；C反应蛋白水平升高，脑卒中患者预后不良的风险升高2.01倍，95％ C I为1.89～3.66。结论急性期脑梗死患者入院时的超敏C反应蛋白的水平与神经功能缺损严重程度相关，可能是患者出院时神经功能预后评估的相关预测指标。

The research about the relation between the C-reactive protein and NIHSS scores of admission

Objective To explore the relation between the C‐reactive protein (CRP) and NIHSS scores of admission or 3 weeks after admission .Methods The ischemic stroke patients were collected .And all patients were tested to get the CRP level in 24 hours after admission ,and the NIHSS scores of admission or 3 weeks after admission .Results The severe patients had higher CRP level than the others (5 .59 ± 3 .72) vs (4 .30 ± 2 .34)] .The patients having bad neurological prognosis after 3 weeks in hospital have higher CRP level than the other patients (7 .20 ± 4 .01) vs (2 .97 ± 1 .65)] .Logistic regression results showed that ,when the CRP increase ,the risk that patients had severe stroke increased 1.56 times ,and the 95% CI value is 1.13~2.18;The risk of stroke patients had poor prognosis increased 2.01 times ,and the 95% CI value is 1.89~3.66 .Conclu‐sion C‐reactive protein level was related with the severity of ischemic stroke .The CRP level was also the important risk factor for ischemic stroke patients’ prognosis .