High-dose melphalan and autologous bone marrow transplant for relapsed acute leukaemia |
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Authors: | Dominique Maraninchi Manuel Abecasis Jean-Albert Gastaut Gérard Sebahoun Jean-Yves Cahn Patrick Hervé Gisèle Novakovitch Yves Carcassonne |
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Institution: | (1) Institut Paoli-Calmettes, 232, Boulevard de Sainte Marguerite, F-13273 Marseille Cedex 9;(2) Centre Régional de Transfusion Sanguine, 25, rue Mégevand, F-25003 Besançon;(3) Centre, Régional de Transfusion Sanguine, Boulevard Baille, F-13005 Marseille, France |
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Abstract: | Summary Seven patients with relapsed acute leukaemia were treated with high-dose melphalan (HDM) followed by the infusion of autologous cryopreserved remission marrow. Toxicy was minimal and all seven patients had a complete response. Four patients are still in unmaintained remission at 14, 13, 10, and 3 months, the first two having received a second course of HDM to consolidate the result. The role of HDM as a form of intensification therapy for patients with acute myeloid leukaemia in first remission should be investigated. |
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