重型颅脑损伤患者免疫功能状态的临床观察

目的观察重型颅脑损伤患者T淋巴细胞亚群及免疫球蛋白的变化，探讨其临床意义。方法对48例重型颅脑损伤患者于康复治疗前后检测外周血T细胞亚群及免疫球蛋白水平，与对照组比较，结合临床评估分析免疫功能状态在病情及预后评估中的作用。结果重型颅脑损伤患者康复治疗前细胞及体液免疫功能均明显抑制，CD

A clinical study of immunestate on severe traumatic brain injury

Objective: To measure the level of T-lymphocyte subsets and immunoglobulin in severe traumatic brain injury and to explore the clinical significance. Method: 48 cases with severe traumatic brain injury were measured in T-lymphocyte subsets and immunoglobulin of vein blood before and after the rehabilitation therapy. By comparing with the control group and combining clinical evaluation to analyze the immune functional state in the state of TBI and the prognosis. Result:The cellular and humoral immune were inhibited distinctly. The level of CD3 + ,CD4 + ,CD4 +/CD8 +, IgG and IgA of TBI group were lower than the level of the control group. In prognosis, the early immune state of severe disability+vegetable state group was inhibited more seriously than good recovery + mild disability group. Conclusion: The cellular and humoral immune of severe traumatic brain injury were in inhibited state. The severe inhibition of immune, the worse the prognosis.