雌激素水平与绝经后血管性痴呆患者认知功能的关系

目的探讨雌激素(E)水平与绝经后血管性痴呆(VD)患者认知功能的关系。方法绝经后VD患者48例,随机分为VD1组和VD2组各24例,分别给予维尼安2mg与安慰剂1片口服,每月2次,治疗4个月;绝经后健康妇女18例为正常组。3组分别于治疗前及治疗后2和4个月时测定血浆雌二醇水平(E2)和低密度脂蛋白胆固醇(LDLC)水平,简易智能量表(MMSE)测定认知功能。结果VD组患者E2水平明显低于正常组(P<0.05)。VD1组经过维尼安治疗4个月后,E2水平逐渐上升(P<0.01),LDLC逐渐下降(P<0.05),MMSE评分逐渐提高(P<0.05);E2水平与LDLC水平呈显著负相关性(P<0.01);与MMSE评分呈正相关性(P<0.05)。结论E替代治疗有利于改善绝经后VD患者的认知功能。

Relationship between Estrogen and Cognition of Post-menopausal Women with Vascular Dementia

Objective: To study the relationship between estrogen level and cognition of post menopausal women with vascular dementia (VD). Methods: Forty eight VD cases were assigned to two groups randomly: VD1 and VD2 group who were subjected to nilestrial replacement therapy or placebo treatment respectively for 4 months. At the 0, 2nd and 4th month of treatment, serous estradiol (E 2) and low density lipoprotein cholesterol (LDL C) levels were measured, and cognition was measured by mini mental state examination (MMSE) too. Results: E 2 level in the VD group was lower than that in the normal group ( P <0.05). After nilestrial treatment, E 2 level was increased ( P <0.01), and LDL C level decreased ( P <0.05)in the VD1 group. Meanwhile, MMSE was raised ( P <0.05). There was a significant negative correlation between E 2 level and LDL C level ( P <0.01), while a positive correlation between E 2 level and MMSE ( P <0.05). Conclusion: Estrogen replacement therapy is effective to cognition of post menopausal women with VD.