失眠颗粒对昼夜节律紊乱性睡眠障碍的调节作用研究

目的:探讨失眠颗粒对昼夜节律紊乱性睡眠障碍的调节作用。方法:选取符合西医昼夜节律失调性睡眠障碍诊断的医护人员60名,随机分为对照组和治疗组各30例。对照组和治疗组在给予简单的认知行为疗法及睡眠指导常规治疗,在此基础上对照组口服安慰剂,治疗组口服失眠颗粒。观察两组治疗前后ESS(爱泼沃思睡量表)、ISI(失眠严重指数量表)、PSQI评分(匹兹堡睡眠质量指数)及中医症状评分等指标。结果:治疗组总有效率为93.33%高于对照组的83.33%,两组间治疗后差异有统计学意义(P<0.05)。两组患者ESS评分、ISI评分、PSQI评分均显著降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗后,两组患者的中医症状评分降低(P<0.05);治疗后治疗组症状评分大多低于对照组(P<0.05)。结论:对于昼夜节律紊乱性睡眠障碍患者治疗疗效显著,具有疏肝清热、养心安神的功效,治疗过程中不良反应少,安全性能高。

Regulatory effect of insomnia granule on circadian rhythm disorder sleep disorder

Objective: To Investigate the regulatory effect of insomnia granule on circadian rhythm disorder. Methods: 60 medical workers who were diagnosed with circadian dysrhythmia sleep disorder were stochastic divided into control group and treatment group,30 cases each.The control group and the treatment group were given simple cognitive behavioral therapy and routine sleep guidance therapy,on this basis,the control group was given oral placebo,and the treatment group was given oral insomnia granules.ESS(epworth sleep scale),ISI (severe insomnia index scale),PSQI score (Pittsburgh sleep quality index) and TCM symptom score were looked into before treatment and after treatment. Results :The total effective rate of the treatment group was 93.33%,which was significantly higher than that of the control group (83.33%),with statistical difference between the two groups ( P <0.05).After treatment,ESS score,ISI score and PSQI score in both groups were significantly reduced ( P <0.05),and the treatment group was lower than the control group( P <0.05).After treatment,the TCM symptom scores of the two groups were decreased ( P <0.05).After treatment,the symptom scores of the treatment group were mostly lower than those of the control group( P <0.05). Conclusion:It has significant therapeutic effect on patients with circadian rhythm disorder sleep disorder,and has the effect of soothing the liver,clearing heat,nourishing the heart and calming the mind. In the process of treatment,there are few adverse reactions and high safety performance,so it has clinical application value.