急性白血病患者血清sIL-2R,MCP-1及IFN-γ联合检测的临床意义

目的 探讨急性白血病患者血清可溶性白细胞介素-2受体(soluble interleukin-2 receptors,sIL-2R),单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1)及γ-干扰素(interferon-γ,IFN-γ)联合检测的临床意义。方法 选取2015年6月～2018年7月收治的急性白血病患者86例为观察组,另选同期接受体检的健康者86例为对照组,对两组血清sIL-2R,MCP-1及 IFN-γ水平予以检测,并观察三种指标联合检测与单独检测的诊断准确度、特异度、灵敏度。结果 观察组血清sIL-2R,MCP-1和IFN-γ分别为492.57±35.28 U/ml,18.25±2.71 μg/L和16.32±3.02 pg/ml,与对照组156.31±18.45 U/ml,4.91±0.93 μg/L和33.46±5.28 pg/ml对比,差异均有统计学意义(t=78.325,43.178,26.132,均P<0.01); 急性淋巴细胞白血病患者血清sIL-2R,MCP-1和IFN-γ分别为563.18±39.54 U/ml,22.53±2.85 μg/L和10.26±2.14 pg/ml,与急性髓细胞白血病患者(431.27±33.17 U/ml,14.74±2.69 μg/L和18.63±2.51 pg/ml)对比,差异均有统计学意义(t=23.702,18.434,23.532,均P<0.01); sIL-2R,MCP-1和IFN-γ联合检测准确度、特异度和灵敏度分别为86.05%,87.04%和84.38%,与单项检测对比,均明显升高,差异有统计学意义(P<0.05)。结论 急性白血病患者血清sIL-2R,MCP-1及 IFN-γ水平存在明显异常,且不同类型急性白血病患者上述指标有较大差异,三者联合检测在急性白血病诊断中具有较高价值。

Clinical Significance of Combined Detection of Serum sIL-2R,MCP-1and IFN-gamma in Patients with Acute Leukemia

Objective To explore the value of combined detection of soluble interleukin-2 receptor(soluble interleukin-2 receptors,sIL-2R),monocyte chemoattractant protein-1(monocyte chemotactic protein-1,MCP-1)and interferon-gamma(interferon-γ,IFN-γ)in patients with acute leukemia.Methods 86 patients with acute leukemia admitted from June 2015 to July 2018 were selected as the observation group and 86 healthy subjects were selected as the control group at the same time.The serum levels ofsIL-2R,MCP-1 and IFN-γ were detected in the two groups,and the diagnosticaccuracy,specificity and sensitivity of the combined detection and separate detection of the three indexes were observed.Results The serum levels of sIL-2R,MCP-1 and IFN-γ in the observation group were respectively 492.57±35.28 U/ml,18.25±2.71 μg/L and 16.32±3.02 pg/ml,respectively,compared with those 156.31±18.45 U/ml,4.91±0.93 μg/L and 33.46±5.28 pg/ml in the control group,the difference was significant(t=78.325,43.178,26.132,all P<0.01).The levels of serum sIL-2R,MCP-1 and IFN-γ in patients with acute lymphoblastic leukemia were respectively 563.18±39.54 U/ml,22.53±2.85 μg/L and 10.26 ±2.14 pg/ml,respectively,which were significantly different from those in patients with acute myeloid leukemia 431.27±33.17 U/ml,14.74±2.69 μg/L and 18.63±2.51 pg/ml(t=23.702,18.434,23.532,all P<0.01).The accuracy,specificity and sensitivity of combined detection of sIL-2R,MCP-1 and IFN-γ were 86.05%,87.04% and 84.38%,respectively,which were significantly higher than those of single detection(P<0.05).Conclusion The serum levels of sIL-2R,MCP-1 and IFN-γ in patients with acute leukemia were significantly abnormal,and there were significant differences in the above indexes among different types of acute leukemia.The combined detection of the three indexes is of high value in the diagnosis of acute leukemia.