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| 美托洛尔对缺血糖尿病大鼠心肌的电生理作用 | |
| 引用本文： | Jin HF,Zeng WP,Shen FR,Wang ZJ,He L,Sun GJ,Chen JM,Zhong C. 美托洛尔对缺血糖尿病大鼠心肌的电生理作用[J]. 浙江大学学报(医学版), 2011, 40(6): 653-658. DOI: 10.3785/j.issn.1008-9292.2011.06.013 |
| 作者姓名： | Jin HF Zeng WP Shen FR Wang ZJ He L Sun GJ Chen JM Zhong C |
| 作者单位： | 浙江医院,浙江杭州,310013 |
| 摘 要： | 目的:研究美托洛尔对糖尿病大鼠心肌缺血缺氧的电生理作用及其机制.方法:雄性Sprague-Dawley (SD)大鼠40只,实验分为:糖尿病组、糖尿病+左交感神经切除组、糖尿病+美托洛尔组,空白对照组,每组10只大鼠.通过腹腔注射链脲佐菌素(60 mg/kg)建立糖尿病模型,模型建立后行离体的心脏的电生理研究.分别测定心室舒张期兴奋阈( Diastolic effective threshold,DET),心室有效不应期(Effective refractive period,ERP),心室颤动阈(Ventricular fibrillation threshold,VFT),并测定各组的血清神经生长因子(nerve growth factor,NGF)浓度.结果:美托洛尔可以提高糖尿病大鼠心肌缺血后的DET,交感神经切除组可以明显提高糖尿病大鼠的VFT,具有统计学差异.美托洛尔组的VFT比糖尿病大鼠的VFT明显升高,心肌缺血前,关托洛尔组的VFT和糖尿病组的VFT比较并没有差异.缺血后,美托洛尔组的VFT比糖尿病大鼠的VFT明显升高,糖尿病组及糖尿病+美托洛尔组大鼠其NGF浓度明显高于对照组,具有统计学差异;而糖尿病+交感神经切除组大鼠,其NGF浓度与对照组间差异没有显著性.结论:交感神经的重构对糖尿病大鼠心肌的电生理,特别是对缺血后的电生理的影响发生起到重要的作用,美托洛尔可以提高缺血后糖尿病大鼠的VFT,降低心肌的兴奋阈值,从而可能降低室性心律失常的发生.其机制可能与其抑制交感神经的重构有关. |
| 关 键 词： | 美托洛尔/治疗应用 心肌缺血/药物疗法 心肌/代谢 糖尿病 室性心律失常 |
Effects of metoprolol on electrophysiology of ischemic and anoxic myocardium in diabetic rats |
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| Jin Hong-feng,Zeng Wen-ping,Shen Fa-rong,Wang Zhi-jun,He Lang,Sun Guo-jian,Chen Jian-ming,Zhong Cheng. Effects of metoprolol on electrophysiology of ischemic and anoxic myocardium in diabetic rats[J]. Journal of Zhejiang University. Medical sciences, 2011, 40(6): 653-658. DOI: 10.3785/j.issn.1008-9292.2011.06.013 | |
| Authors: | Jin Hong-feng Zeng Wen-ping Shen Fa-rong Wang Zhi-jun He Lang Sun Guo-jian Chen Jian-ming Zhong Cheng |
| Affiliation: | JIN Hong-feng,ZENG Wen-ping,SHEN Fa-rong,WANG Zhi-jun,HE Lang,SUN Guo-jian,CHEN Jian-ming,ZHONG Cheng(Zhejiang Hospital,Hangzhou 310013,China) |
| Abstract: | Objective: To investigate the effects of metoprolol on electrophysiology of ischemic and anoxic myocardium in diabetic rats. Methods: Forty Sprague-Dawley(SD) rats were divided into 4 groups:diabetes group;diabetes and ablation of left sympathetic nerve group;diabetes and metoprolol group and sham group.The diabetes model was induced by intraperitoneal injection of streptozotocin(STZ,60 mg/kg).The ventricular diastolic effective threshold(DET),effective refractive period(ERP),and Ventricular fibrillation th... |
| Keywords: | Metoprolol/thera use Myocardial ischemia/drug ther Myocardium/metab Diabetes mellitus Ventricular arrhythmia |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |