Synthesis and pharmacological activity of 1-(4-substituted phenyl)-1-alkyl(aryl)-3-piperidinopropanol hydrochlorides |
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| Authors: | N. K. Gasparyan R. G. Paronikyan A. E. Tumadzhyan A. A. Tatevosyan G. A. Panosyan G. A. Gevorgyan |
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| Affiliation: | (1) Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, 131 Princess Street, M1 7DN, UK;(2) Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK;(3) Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK |
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| Abstract: | Aminomethylation of substituted acetophenones with paraformaldehyde and piperidine hydrochloride yielded 4-substituted β-piperidinopropiophenones. Interaction of compounds I with the Grignard reagents in ether yielded 1-(4-substituted phenyl)-1-alkyl(aryl)-3-piperidinopropanols. The anti-inflammatory, analgesic, antipyretic, central m-cholinoblocking, and peripheral n-cholinoblocking actions of 1-(4-substituted phenyl)-1-alkyl(aryl)-3-piperidinopropanol hydrochlorides were studied. The study compounds were found to have marked central m-cholinoblocking and peripheral n-cholinoblocking activities. Only 1-(4-methoxyphenyl)-1-cyclohexyl-3-piperidinopropanol hydrochloride had anti-inflammatory activity. |
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