大蒜汁雾化吸入联合GP方案治疗中晚期非小细胞肺癌57例疗效观察

【目的】观察大蒜汁雾化吸入联合GP方案吉西他滨（GEM）＋顺铂（DDP）]治疗中晚期非小细胞肺癌（NSCLC）的临床疗效、不良反应及对白细胞介素一6（IL一6）的影响。【方法】将113例中晚期NSCLC患者随机分为两组，治疗组（57例）采用大蒜汁雾化吸入加GP方案治疗，对照组（56例）采用单纯GP方案化疗。【结果】治疗组和对照组的有效率（CR＋PR）分别为45．6％和33．9％（P〉O．05），临床获益率（CR＋PR＋SD）分别为80．7％和64．3％（P〈0．05）。治疗后治疗组IL一6明显降低（P〈0．05）；治疗组生存质量高于对照组（P〈0．05）；对照组白细胞减少、血红蛋白下降和恶心、呕吐等病例数多于治疗组（P〈0．05）。【结论】大蒜汁雾化吸入与化疗同时应用治疗NSCLC，能降低炎症因子IL一6及减轻化疗的某些不良反应，提高临床获益率，改善患者生存质量。

Observation on the Efficacy of Atomized Inhalation of Water Extract from Garlic with GP Regimen in Treating 57 Cases with Advanced Non-small Cell Lung Cancer

ObjectiveITo observe the clinical efficacy and adverse reaction of atomized inhalation of water extract form garlic combined with GP regimen gemcitabine（GEM） and cisplatin（DDP） for treating middle and advanced non-small lung cancer（NSCLC） and its effect on interleukin-6 （IL-6）. Methods]Totally 113 cases of middle and advanced NSCLC were randomly divided into two groups. The treatment group（ n =57） was given atomized inhalation of water extract from garlic combined with GP regimen. The control group（ n =56） was given only GP regimen. ResultsIThe effective rate（CR＋ PR） in treatment group and control group was 45.6% and 33.9%, respectively（ P〉0. 05）. The clinical benefit response rate（CR＋PR＋SD） in treatment group and control group was 80.7% and 64.3%, respectively（ P〈0.05）. After therapy, the level of IL-6 in treatment group significantly decreased（ P〈0.05）. The quality of life in treatment group was better than that in control group（ P〈0.05）. The incidence of leucopenia, hypohemoglobinemia, nausea and vomiting in con- trol group were higher than those in treatment group（ P d0.05）. ConclusionIAtomized inhalation of water extract from garlic combined with chemotherapy for the treatment of NSCLC can decrease the level of IL-6 and some side effects, increase the clinical benefit response rate and improve the quality of life of the patients.