Effect of TRK-100, a prostacyclin analogue, on endotoxin-induced enhancement of blood coagulation in rats |
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| Authors: | A Sakai T Hori T Okuda T Matsubara K Saitoh M Yajima S Nishio |
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| Affiliation: | Central Research Institute, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan. |
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| Abstract: | ![]()
TRK-100 (0.03, 0.1 and 0.3 mg/kg, p.o.), a chemically stable analogue of prostacyclin, dose-dependently prevented blood coagulation and glomerular fibrin deposition which were enhanced by 4 hr infusion of endotoxin (100 mg/kg) in rats. In addition, TRK-100 suppressed the generation of endotoxin-induced tissue thromboplastin like activity in cultured human endothelial cells. |
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